About Enhancer
| Enhancer ID: | E_01_0494 |
| Species: | mouse |
| Position : | chr9:63857441-63859441   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Nothing |
| Pubmed ID: | 29749927 |
| Enhancer experiment: | FACS,Immunofluorescence staining,Elisa,Immunoblot,qPCR,RNA-seq,T-WGBS,MassARRAY,Interactome analysis, |
| Enhancer experiment description: | Functional experiments prototypically validated the strongly epigenetically regulated inhibitors of TGF? family signaling SMAD6 and SMAD7 as regulators of EC quiescence. These data establish the transcriptional and epigenetic landscape of vascular quiescence that will serve as a foundation for further mechanistic studies of vascular homeostasis and disease-associated activation. |
About Target gene
| Target gene : | Smad6,Smad7 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Functional experiments prototypically validated the strongly epigenetically regulated inhibitors of TGF? family signaling SMAD6 and SMAD7 as regulators of EC quiescence. These data establish the transcriptional and epigenetic landscape of vascular quiescence that will serve as a foundation for further mechanistic studies of vascular homeostasis and disease-associated activation.;Functional experiments prototypically validated the strongly epigenetically regulated inhibitors of TGF? family signaling SMAD6 and SMAD7 as regulators of EC quiescence. These data establish the transcriptional and epigenetic landscape of vascular quiescence that will serve as a foundation for further mechanistic studies of vascular homeostasis and disease-associated activation. |
About TF
| TF name : | -- |
| TF experiment: | FACS,Immunofluorescence staining,Elisa,Immunoblot,qPCR,RNA-seq,T-WGBS,MassARRAY,Interactome analysis, |
| TF experiment description: | Functional experiments prototypically validated the strongly epigenetically regulated inhibitors of TGF? family signaling SMAD6 and SMAD7 as regulators of EC quiescence. These data establish the transcriptional and epigenetic landscape of vascular quiescence that will serve as a foundation for further mechanistic studies of vascular homeostasis and disease-associated activation.;Functional experiments prototypically validated the strongly epigenetically regulated inhibitors of TGF? family signaling SMAD6 and SMAD7 as regulators of EC quiescence. These data establish the transcriptional and epigenetic landscape of vascular quiescence that will serve as a foundation for further mechanistic studies of vascular homeostasis and disease-associated activation. |
About Function
| Enhancer function : | Functional experiments prototypically validated the strongly epigenetically regulated inhibitors of TGF? family signaling SMAD6 and SMAD7 as regulators of EC quiescence. These data establish the transcriptional and epigenetic landscape of vascular quiescence that will serve as a foundation for further mechanistic studies of vascular homeostasis and disease-associated activation. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Functional experiments prototypically validated the strongly epigenetically regulated inhibitors of TGF? family signaling SMAD6 and SMAD7 as regulators of EC quiescence. These data establish the transcriptional and epigenetic landscape of vascular quiescence that will serve as a foundation for further mechanistic studies of vascular homeostasis and disease-associated activation. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene