About Enhancer
| Enhancer ID: | E_01_0502 |
| Species: | mouse |
| Position : | chr9:21137636-21139636   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Nothing |
| Pubmed ID: | 29742982 |
| Enhancer experiment: | real-time PCR,Protein isolation,Western immunoblotting,immunohistochemistry,analysis of protein oxidation,RNA interference,Chromatin immunoprecip,Cell transfections,reporter assay,CRISPR/Cas9, |
| Enhancer experiment description: | Nrf2 exerts pleiotropic roles in the thyroid gland to couple cell stress defense mechanisms to iodide metabolism and the thyroid hormone synthesis machinery, both under basal conditions and in response to excess iodide. |
About Target gene
| Target gene : | Keap1,Tg |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Nrf2 exerts pleiotropic roles in the thyroid gland to couple cell stress defense mechanisms to iodide metabolism and the thyroid hormone synthesis machinery, both under basal conditions and in response to excess iodide.;Nrf2 exerts pleiotropic roles in the thyroid gland to couple cell stress defense mechanisms to iodide metabolism and the thyroid hormone synthesis machinery, both under basal conditions and in response to excess iodide.;Nrf2 exerts pleiotropic roles in the thyroid gland to couple cell stress defense mechanisms to iodide metabolism and the thyroid hormone synthesis machinery, both under basal conditions and in response to excess iodide. |
About TF
| TF name : | NFE2(NF-E2,p45) |
| TF experiment: | real-time PCR,Protein isolation,Western immunoblotting,immunohistochemistry,analysis of protein oxidation,RNA interference,Chromatin immunoprecip,Cell transfections,reporter assay,CRISPR/Cas9, |
| TF experiment description: | Nrf2 exerts pleiotropic roles in the thyroid gland to couple cell stress defense mechanisms to iodide metabolism and the thyroid hormone synthesis machinery, both under basal conditions and in response to excess iodide.;Nrf2 exerts pleiotropic roles in the thyroid gland to couple cell stress defense mechanisms to iodide metabolism and the thyroid hormone synthesis machinery, both under basal conditions and in response to excess iodide.;Nrf2 exerts pleiotropic roles in the thyroid gland to couple cell stress defense mechanisms to iodide metabolism and the thyroid hormone synthesis machinery, both under basal conditions and in response to excess iodide. |
About Function
| Enhancer function : | Nrf2 exerts pleiotropic roles in the thyroid gland to couple cell stress defense mechanisms to iodide metabolism and the thyroid hormone synthesis machinery, both under basal conditions and in response to excess iodide. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Nrf2 exerts pleiotropic roles in the thyroid gland to couple cell stress defense mechanisms to iodide metabolism and the thyroid hormone synthesis machinery, both under basal conditions and in response to excess iodide. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NFE2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene