About Enhancer

Enhancer ID: E_01_0505
Species: human
Position : chr1:206764791-206766791
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Coronary artery disease (cad), atherosclerosis
Pubmed ID:  29739060
Enhancer experiment: Quantitative real-time PCR,ELISA,
Enhancer experiment description: Our findings suggested a potential role of miR-10a in the inflammatory process underlying atherosclerosis; however, more studies are needed to support these finding.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: Our findings suggested a potential role of miR-10a in the inflammatory process underlying atherosclerosis; however, more studies are needed to support these finding.

About TF

TF name : IL10
TF experiment: Quantitative real-time PCR,ELISA,
TF experiment description: Our findings suggested a potential role of miR-10a in the inflammatory process underlying atherosclerosis; however, more studies are needed to support these finding.

About Function

Enhancer function : Our findings suggested a potential role of miR-10a in the inflammatory process underlying atherosclerosis; however, more studies are needed to support these finding.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:
Our findings suggested a potential role of miR-10a in the inflammatory process underlying atherosclerosis; however, more studies are needed to support these finding.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
IL10 AP-1 transcription factor network pid 71
IL10 Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin) ( GPCR signaling (pertussis toxin) ) inoh 228
IL10 Heterotrimeric GPCR signaling pathway (through G alpha q, PLC beta and ERK cascade) ( GPCR signaling (G alpha q) ) inoh 239
IL10 Heterotrimeric GPCR signaling pathway (through G alpha s ACs Epac BRaf and ERKcascade) ( GPCR signaling (G alpha s, Epac and ERK) ) inoh 237
IL10 Heterotrimeric GPCR signaling pathway (through_G alpha s_ACs_PKA_BRaf_and_ERKcascade)(canonical) ( GPCR signaling (G alpha s, PKA and ERK) ) inoh 227
IL10 Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through G alpha i, adenylate cyclase and cAMP) ( GPCR signaling (G alpha i) ) inoh 228
IL10 Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through_G_alpha_s,_cholera_toxin,_adenylate_cyclase_and_cAMP) ( GPCR signaling (cholera toxin) ) inoh 227
IL10 IL-10 signaling pathway(JAK1 TYK2 STAT3) ( IL-10 signaling(JAK1 TYK2 STAT3) ) inoh 6
IL10 IL4-mediated signaling events pid 66
IL10 Interleukin signaling pathway panther 86
IL10 JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 97
IL10 Regulation of nuclear SMAD2/3 signaling pid 82
IL10 Cytokine-cytokine receptor interaction kegg 213
IL10 Jak-STAT signaling pathway kegg 149
IL10 T cell receptor signaling pathway kegg 105
IL10 Intestinal immune network for IgA production kegg 48
IL10 Leishmaniasis kegg 71
IL10 Chagas disease kegg 103
IL10 Malaria kegg 50
IL10 Toxoplasmosis kegg 131
IL10 Amoebiasis kegg 103
IL10 Staphylococcus aureus infection kegg 54
IL10 Asthma kegg 29
IL10 Autoimmune thyroid disease kegg 52
IL10 Systemic lupus erythematosus kegg 136
IL10 Allograft rejection kegg 37
IL10 Hs_Osteoblast_Signaling_WP322_90527 wikipathways 10
IL10 Hs_Signaling_of_Hepatocyte_Growth_Factor_Receptor_WP313_79946 wikipathways 15
IL10 Hs_Hypertrophy_Model_WP516_88898 wikipathways 17
IL10 Hs_Regulation_of_Actin_Cytoskeleton_WP51_79977 wikipathways 36

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs