About Enhancer
| Enhancer ID: | E_01_0516 |
| Species: | human |
| Position : | chr8:127791607-127793607   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Mammary cancer |
| Pubmed ID: | 29731168 |
| Enhancer experiment: | RNA-seq,Rearrangement analysis,Hi-ChIP,UMI-4C,4C-Seq,Luciferase reporter assay,CRISPR/Cas9,4sU-labeling,JQ1 treatment,ChIP,ATAC-seq,Northern blot,Cell growth competition assay,Western blot,qRT-PCR,siRNA,ASO, |
| Enhancer experiment description: | Cancer genome sequencing identifies recurrent mutations encompassing the human PVT1 promoter, and genome editing verified that PVT1 promoter mutation promotes cancer cell growth. These results highlight regulatory sequences of lncRNA genes as potential disease-associated DNA elements. |
About Target gene
| Target gene : | PVT1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Cancer genome sequencing identifies recurrent mutations encompassing the human PVT1 promoter, and genome editing verified that PVT1 promoter mutation promotes cancer cell growth. These results highlight regulatory sequences of lncRNA genes as potential disease-associated DNA elements. |
About TF
| TF name : | -- |
| TF experiment: | RNA-seq,Rearrangement analysis,Hi-ChIP,UMI-4C,4C-Seq,Luciferase reporter assay,CRISPR/Cas9,4sU-labeling,JQ1 treatment,ChIP,ATAC-seq,Northern blot,Cell growth competition assay,Western blot,qRT-PCR,siRNA,ASO, |
| TF experiment description: | Cancer genome sequencing identifies recurrent mutations encompassing the human PVT1 promoter, and genome editing verified that PVT1 promoter mutation promotes cancer cell growth. These results highlight regulatory sequences of lncRNA genes as potential disease-associated DNA elements. |
About Function
| Enhancer function : | Cancer genome sequencing identifies recurrent mutations encompassing the human PVT1 promoter, and genome editing verified that PVT1 promoter mutation promotes cancer cell growth. These results highlight regulatory sequences of lncRNA genes as potential disease-associated DNA elements. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Cancer genome sequencing identifies recurrent mutations encompassing the human PVT1 promoter, and genome editing verified that PVT1 promoter mutation promotes cancer cell growth. These results highlight regulatory sequences of lncRNA genes as potential disease-associated DNA elements. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene