About Enhancer
| Enhancer ID: | E_01_0536 |
| Species: | mouse |
| Position : | chr16:23780812-23782812   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Asthma |
| Pubmed ID: | 29696026 |
| Enhancer experiment: | Fluorescence-activated cell sorting(Facs) analysis,chromatin immunoprecipitation(ChIP),ELISA,retroviral Vectors With a d2EGFP reporter gene,Western Blot,OVA Challenge,Bronchoalveolar lavage (BAL),Histologic Examination,transgenic mice, |
| Enhancer experiment description: | The inhibitory functions of Bcl6 in MPT and MPTH2 cells attenuated allergic responses. Bcl6 is a critical regulator of IL-4 production by MPT and MPTH2 cells in TH2 immune responses related to the pathogenesis of allergies. |
About Target gene
| Target gene : | Bcl6(BCL5A,LAZ3,ZBTB27,ZNF51,BCL6) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | The inhibitory functions of Bcl6 in MPT and MPTH2 cells attenuated allergic responses. Bcl6 is a critical regulator of IL-4 production by MPT and MPTH2 cells in TH2 immune responses related to the pathogenesis of allergies. |
About TF
| TF name : | -- |
| TF experiment: | Fluorescence-activated cell sorting(Facs) analysis,chromatin immunoprecipitation(ChIP),ELISA,retroviral Vectors With a d2EGFP reporter gene,Western Blot,OVA Challenge,Bronchoalveolar lavage (BAL),Histologic Examination,transgenic mice, |
| TF experiment description: | The inhibitory functions of Bcl6 in MPT and MPTH2 cells attenuated allergic responses. Bcl6 is a critical regulator of IL-4 production by MPT and MPTH2 cells in TH2 immune responses related to the pathogenesis of allergies. |
About Function
| Enhancer function : | The inhibitory functions of Bcl6 in MPT and MPTH2 cells attenuated allergic responses. Bcl6 is a critical regulator of IL-4 production by MPT and MPTH2 cells in TH2 immune responses related to the pathogenesis of allergies. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
The inhibitory functions of Bcl6 in MPT and MPTH2 cells attenuated allergic responses. Bcl6 is a critical regulator of IL-4 production by MPT and MPTH2 cells in TH2 immune responses related to the pathogenesis of allergies. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene