About Enhancer
| Enhancer ID: |
E_01_0574 |
| Species: |
human |
| Position :
|
chr17:39755055-39757055
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
Inflammatory |
| Pubmed ID: |
32321757
|
| Enhancer experiment: |
Flow cytometry?RNA isolation?Luciferase assay?quantitative PCR |
| Enhancer experiment description: |
Pharmacological targeting of IKZF3 with the drug lenalidomide showed that IKZF3 is required for anti-CD3/CD28 mAb mediated induction of IL-10 but is dispensable for ex vivo IL-10 expression. |
About Target gene
| Target gene : |
-- |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
Pharmacological targeting of IKZF3 with the drug lenalidomide showed that IKZF3 is required for anti-CD3/CD28 mAb mediated induction of IL-10 but is dispensable for ex vivo IL-10 expression. |
About TF
| TF name : |
IKZF3 |
| TF experiment: |
Flow cytometry?RNA isolation?Luciferase assay?quantitative PCR |
| TF experiment description: |
Pharmacological targeting of IKZF3 with the drug lenalidomide showed that IKZF3 is required for anti-CD3/CD28 mAb mediated induction of IL-10 but is dispensable for ex vivo IL-10 expression. |
About Function
| Enhancer function : |
Pharmacological targeting of IKZF3 with the drug lenalidomide showed that IKZF3 is required for anti-CD3/CD28 mAb mediated induction of IL-10 but is dispensable for ex vivo IL-10 expression. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
Pharmacological targeting of IKZF3 with the drug lenalidomide showed that IKZF3 is required for anti-CD3/CD28 mAb mediated induction of IL-10 but is dispensable for ex vivo IL-10 expression. |
About SNP
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs