About Enhancer
| Enhancer ID: | E_01_0576 |
| Species: | human |
| Position : | chr3:12285010-12287010   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Adipogenesis |
| Pubmed ID: | 32326648 |
| Enhancer experiment: | Immunophenotypic Characterisation?RT-PCR?qRT-PCR?RNA Seq |
| Enhancer experiment description: | While DPSCs differentiated readily along osteogenic and chondrogenic pathways, after 21 days in two different types of adipogenic induction media, DPSCs cultures did not contain lipid vacuoles and had low expression levels of the adipogenic genes proliferator-activated receptor gamma (PPARG), lipoprotein lipase (LPL) and CCAAT/enhancer-binding protein alpha (CEBPA). |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | While DPSCs differentiated readily along osteogenic and chondrogenic pathways, after 21 days in two different types of adipogenic induction media, DPSCs cultures did not contain lipid vacuoles and had low expression levels of the adipogenic genes proliferator-activated receptor gamma (PPARG), lipoprotein lipase (LPL) and CCAAT/enhancer-binding protein alpha (CEBPA). |
About TF
| TF name : | PPARG |
| TF experiment: | Immunophenotypic Characterisation?RT-PCR?qRT-PCR?RNA Seq |
| TF experiment description: | While DPSCs differentiated readily along osteogenic and chondrogenic pathways, after 21 days in two different types of adipogenic induction media, DPSCs cultures did not contain lipid vacuoles and had low expression levels of the adipogenic genes proliferator-activated receptor gamma (PPARG), lipoprotein lipase (LPL) and CCAAT/enhancer-binding protein alpha (CEBPA). |
About Function
| Enhancer function : | While DPSCs differentiated readily along osteogenic and chondrogenic pathways, after 21 days in two different types of adipogenic induction media, DPSCs cultures did not contain lipid vacuoles and had low expression levels of the adipogenic genes proliferator-activated receptor gamma (PPARG), lipoprotein lipase (LPL) and CCAAT/enhancer-binding protein alpha (CEBPA). |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
While DPSCs differentiated readily along osteogenic and chondrogenic pathways, after 21 days in two different types of adipogenic induction media, DPSCs cultures did not contain lipid vacuoles and had low expression levels of the adipogenic genes proliferator-activated receptor gamma (PPARG), lipoprotein lipase (LPL) and CCAAT/enhancer-binding protein alpha (CEBPA). |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| PPARG | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| PPARG | Noncanonical Wnt signaling pathway | pid | 33 |
| PPARG | Nuclear Receptor transcription pathway | reactome | 51 |
| PPARG | PPARA activates gene expression | reactome | 113 |
| PPARG | Regulation of retinoblastoma protein | pid | 67 |
| PPARG | RXR and RAR heterodimerization with other nuclear receptor | pid | 26 |
| PPARG | Signaling events mediated by HDAC Class I | pid | 89 |
| PPARG | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| PPARG | Wnt | netpath | 118 |
| PPARG | PPAR signaling pathway | kegg | 67 |
| PPARG | Huntington's disease | kegg | 182 |
| PPARG | Pathways in cancer | kegg | 321 |
| PPARG | Thyroid cancer | kegg | 25 |
| PPARG | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
| PPARG | Hs_p38_MAPK_Signaling_Pathway_WP400_72084 | wikipathways | 28 |
| PPARG | Hs_Nucleotide_Metabolism_WP404_68960 | wikipathways | 16 |
| PPARG | Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 | wikipathways | 9 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene