About Enhancer
| Enhancer ID: | E_01_0652 |
| Species: | human |
| Position : | chr7:148804504-148806504   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Calcification of the ligamentum flavum (clf) |
| Pubmed ID: | 30368870 |
| Enhancer experiment: | -- |
| Enhancer experiment description: | These findings indicated that ANCR upregulates EZH2 expression and physically binds to EZH2 in LF MSCs to suppress chondrogenic differentiation and calcification. Therefore, downregulated ANCR contributes to increasing of chondrocyte like cells and calcium deposition in CLF. ANCR may serve as a therapeutic target for CLF. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | These findings indicated that ANCR upregulates EZH2 expression and physically binds to EZH2 in LF MSCs to suppress chondrogenic differentiation and calcification. Therefore, downregulated ANCR contributes to increasing of chondrocyte like cells and calcium deposition in CLF. ANCR may serve as a therapeutic target for CLF. |
About TF
| TF name : | EZH2(ENX-1,ENX1b,KMT6,KMT6A,WVS,WVS2,EZH2) |
| TF experiment: | -- |
| TF experiment description: | These findings indicated that ANCR upregulates EZH2 expression and physically binds to EZH2 in LF MSCs to suppress chondrogenic differentiation and calcification. Therefore, downregulated ANCR contributes to increasing of chondrocyte like cells and calcium deposition in CLF. ANCR may serve as a therapeutic target for CLF. |
About Function
| Enhancer function : | These findings indicated that ANCR upregulates EZH2 expression and physically binds to EZH2 in LF MSCs to suppress chondrogenic differentiation and calcification. Therefore, downregulated ANCR contributes to increasing of chondrocyte like cells and calcium deposition in CLF. ANCR may serve as a therapeutic target for CLF. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
These findings indicated that ANCR upregulates EZH2 expression and physically binds to EZH2 in LF MSCs to suppress chondrogenic differentiation and calcification. Therefore, downregulated ANCR contributes to increasing of chondrocyte like cells and calcium deposition in CLF. ANCR may serve as a therapeutic target for CLF. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| EZH2 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| EZH2 | Oxidative Stress Induced Senescence | reactome | 120 |
| EZH2 | PKMTs methylate histone lysines | reactome | 64 |
| EZH2 | PRC2 methylates histones and DNA | reactome | 71 |
| EZH2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| EZH2 | Hs_Interactome_of_polycomb_repressive_complex_2_(PRC2)_WP2916_88672 | wikipathways | 15 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene