About Enhancer
| Enhancer ID: | E_01_0676 |
| Species: | human |
| Position : | chr8:56158399-56160399   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Alzheimer disease |
| Pubmed ID: | 30319691 |
| Enhancer experiment: | quantitative trait loci (eQTL)analysis?immunoassay |
| Enhancer experiment description: | Three of the five SNPs were located in promoter or enhancer regions, and transcription factor (TF) binding affinity calculations showed dramatic changes (| Log2FC| > 2) of three TFs (PLAG1, RREB1, and ZBTB33) for two motifs containing SNPs rs2075650 and rs157580. In addition, our GWAS showed that both rs2075650 and rs157580 were significantly associated with the poliovirus receptorrelated 2 (PVRL2) gene (FDR < 0.25), which is involved in spreading of herpes simplex virus (HSV). |
About Target gene
| Target gene : | PLAG1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Three of the five SNPs were located in promoter or enhancer regions, and transcription factor (TF) binding affinity calculations showed dramatic changes (| Log2FC| > 2) of three TFs (PLAG1, RREB1, and ZBTB33) for two motifs containing SNPs rs2075650 and rs157580. In addition, our GWAS showed that both rs2075650 and rs157580 were significantly associated with the poliovirus receptorrelated 2 (PVRL2) gene (FDR < 0.25), which is involved in spreading of herpes simplex virus (HSV). |
About TF
| TF name : | -- |
| TF experiment: | quantitative trait loci (eQTL)analysis?immunoassay |
| TF experiment description: | Three of the five SNPs were located in promoter or enhancer regions, and transcription factor (TF) binding affinity calculations showed dramatic changes (| Log2FC| > 2) of three TFs (PLAG1, RREB1, and ZBTB33) for two motifs containing SNPs rs2075650 and rs157580. In addition, our GWAS showed that both rs2075650 and rs157580 were significantly associated with the poliovirus receptorrelated 2 (PVRL2) gene (FDR < 0.25), which is involved in spreading of herpes simplex virus (HSV). |
About Function
| Enhancer function : | Three of the five SNPs were located in promoter or enhancer regions, and transcription factor (TF) binding affinity calculations showed dramatic changes (| Log2FC| > 2) of three TFs (PLAG1, RREB1, and ZBTB33) for two motifs containing SNPs rs2075650 and rs157580. In addition, our GWAS showed that both rs2075650 and rs157580 were significantly associated with the poliovirus receptorrelated 2 (PVRL2) gene (FDR < 0.25), which is involved in spreading of herpes simplex virus (HSV). |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Three of the five SNPs were located in promoter or enhancer regions, and transcription factor (TF) binding affinity calculations showed dramatic changes (| Log2FC| > 2) of three TFs (PLAG1, RREB1, and ZBTB33) for two motifs containing SNPs rs2075650 and rs157580. In addition, our GWAS showed that both rs2075650 and rs157580 were significantly associated with the poliovirus receptorrelated 2 (PVRL2) gene (FDR < 0.25), which is involved in spreading of herpes simplex virus (HSV). |
About SNP
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene