Enhancer ID: | E_01_0680 |
Species: | human |
Position : | chr3:128476289-128478289 |
Biosample name: | |
Experiment class : | High+Lowthroughput |
Enhancer type: | Enhancer |
Disease: | Human leukemia mutations |
Pubmed ID: | 30301799 |
Enhancer experiment: | Quantitative Real-Time RT-PCR?Quantitative ChIP?Immunofluorescence?Colony Forming Unit Assay?Flow Cytometry |
Enhancer experiment description: | By inducing the generation and function of hematopoietic stem and progenitor cells, the master regulator of hematopoiesis GATA- 2 controls the production of all blood cell types. Heterozygous GATA2 mutations cause immunodeficiency, myelodysplastic syndrome, and acute myeloid leukemia. |
Target gene : | -- |
Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
Less strong evidence: | RNA-Seq |
Target gene experiment description: | By inducing the generation and function of hematopoietic stem and progenitor cells, the master regulator of hematopoiesis GATA- 2 controls the production of all blood cell types. Heterozygous GATA2 mutations cause immunodeficiency, myelodysplastic syndrome, and acute myeloid leukemia. |
TF name : | GATA2(DCML,IMD21,MONOMAC,NFE1B) |
TF experiment: | Quantitative Real-Time RT-PCR?Quantitative ChIP?Immunofluorescence?Colony Forming Unit Assay?Flow Cytometry |
TF experiment description: | By inducing the generation and function of hematopoietic stem and progenitor cells, the master regulator of hematopoiesis GATA- 2 controls the production of all blood cell types. Heterozygous GATA2 mutations cause immunodeficiency, myelodysplastic syndrome, and acute myeloid leukemia. |
Enhancer function : | By inducing the generation and function of hematopoietic stem and progenitor cells, the master regulator of hematopoiesis GATA- 2 controls the production of all blood cell types. Heterozygous GATA2 mutations cause immunodeficiency, myelodysplastic syndrome, and acute myeloid leukemia. |
Enhancer function experiment: | Immunohistochemical staining |
Enhancer function experiment description: |
By inducing the generation and function of hematopoietic stem and progenitor cells, the master regulator of hematopoiesis GATA- 2 controls the production of all blood cell types. Heterozygous GATA2 mutations cause immunodeficiency, myelodysplastic syndrome, and acute myeloid leukemia. |
SNP ID: | -- |
GeneName | Pathway Name | Source | Gene Number |
---|---|---|---|
GATA2 | AP-1 transcription factor network | pid | 71 |
GATA2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
GATA2 | HIF-1-alpha transcription factor network | pid | 67 |
GATA2 | IL3 | netpath | 84 |
GATA2 | Regulation of Androgen receptor activity | pid | 54 |
GATA2 | Signaling events mediated by HDAC Class I | pid | 89 |
GATA2 | Signaling events mediated by HDAC Class II | pid | 58 |
GATA2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |