About Enhancer

Enhancer ID: E_01_0680
Species: human
Position : chr3:128476289-128478289
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Human leukemia mutations
Pubmed ID:  30301799
Enhancer experiment: Quantitative Real-Time RT-PCR?Quantitative ChIP?Immunofluorescence?Colony Forming Unit Assay?Flow Cytometry
Enhancer experiment description: By inducing the generation and function of hematopoietic stem and progenitor cells, the master regulator of hematopoiesis GATA- 2 controls the production of all blood cell types. Heterozygous GATA2 mutations cause immunodeficiency, myelodysplastic syndrome, and acute myeloid leukemia.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: By inducing the generation and function of hematopoietic stem and progenitor cells, the master regulator of hematopoiesis GATA- 2 controls the production of all blood cell types. Heterozygous GATA2 mutations cause immunodeficiency, myelodysplastic syndrome, and acute myeloid leukemia.

About TF

TF name : GATA2(DCML,IMD21,MONOMAC,NFE1B)
TF experiment: Quantitative Real-Time RT-PCR?Quantitative ChIP?Immunofluorescence?Colony Forming Unit Assay?Flow Cytometry
TF experiment description: By inducing the generation and function of hematopoietic stem and progenitor cells, the master regulator of hematopoiesis GATA- 2 controls the production of all blood cell types. Heterozygous GATA2 mutations cause immunodeficiency, myelodysplastic syndrome, and acute myeloid leukemia.

About Function

Enhancer function : By inducing the generation and function of hematopoietic stem and progenitor cells, the master regulator of hematopoiesis GATA- 2 controls the production of all blood cell types. Heterozygous GATA2 mutations cause immunodeficiency, myelodysplastic syndrome, and acute myeloid leukemia.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:
By inducing the generation and function of hematopoietic stem and progenitor cells, the master regulator of hematopoiesis GATA- 2 controls the production of all blood cell types. Heterozygous GATA2 mutations cause immunodeficiency, myelodysplastic syndrome, and acute myeloid leukemia.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
GATA2 AP-1 transcription factor network pid 71
GATA2 Factors involved in megakaryocyte development and platelet production reactome 111
GATA2 HIF-1-alpha transcription factor network pid 67
GATA2 IL3 netpath 84
GATA2 Regulation of Androgen receptor activity pid 54
GATA2 Signaling events mediated by HDAC Class I pid 89
GATA2 Signaling events mediated by HDAC Class II pid 58
GATA2 Hs_Apoptosis_WP254_88977 wikipathways 31

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs