About Enhancer

Enhancer ID: E_01_0681
Species: human
Position : chr9:81581030-81583030
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Malignant melanoma
Pubmed ID:  30301396
Enhancer experiment: Immunohistochemical studies
Enhancer experiment description: Therefore, when evaluating spindle cell tumors in which the differential may include both a melanoma and synovial sarcoma, TLE1 expression should be interpreted with caution and in conjunction with an immunohistochemical panel.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: Therefore, when evaluating spindle cell tumors in which the differential may include both a melanoma and synovial sarcoma, TLE1 expression should be interpreted with caution and in conjunction with an immunohistochemical panel.

About TF

TF name : TLE1
TF experiment: Immunohistochemical studies
TF experiment description: Therefore, when evaluating spindle cell tumors in which the differential may include both a melanoma and synovial sarcoma, TLE1 expression should be interpreted with caution and in conjunction with an immunohistochemical panel.

About Function

Enhancer function : Therefore, when evaluating spindle cell tumors in which the differential may include both a melanoma and synovial sarcoma, TLE1 expression should be interpreted with caution and in conjunction with an immunohistochemical panel.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 Therefore, when evaluating spindle cell tumors in which the differential may include both a melanoma and synovial sarcoma, TLE1 expression should be interpreted with caution and in conjunction with an immunohistochemical panel.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
TLE1 Deactivation of the beta-catenin transactivating complex reactome 42
TLE1 Formation of the beta-catenin:TCF transactivating complex reactome 88
TLE1 Negative regulation of (transcription by R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) inoh 21
TLE1 Notch-mediated HES/HEY network pid 48
TLE1 NOTCH1 Intracellular Domain Regulates Transcription reactome 47
TLE1 Presenilin action in Notch and Wnt signaling pid 46
TLE1 Regulation of nuclear beta catenin signaling and target gene transcription pid 80
TLE1 Repression of WNT target genes reactome 14
TLE1 Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) inoh 47
TLE1 Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) inoh 47
TLE1 Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) inoh 47
TLE1 Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) inoh 47
TLE1 Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 47
TLE1 Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) inoh 47
TLE1 Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) inoh 8
TLE1 Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) inoh 8
TLE1 Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) inoh 8
TLE1 Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) inoh 8
TLE1 Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 8
TLE1 Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) inoh 8
TLE1 Wnt signaling pathway panther 250

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs