About Enhancer
| Enhancer ID: | E_01_0694 |
| Species: | human |
| Position : | chr8:127077104-127079104   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Non small cell lung cancer |
| Pubmed ID: | 30257372 |
| Enhancer experiment: | Cell transfection,RNA isolation,qRT-PCR analysi, Cell proliferation assays, Transwell assays,Luciferase reporter analysis,RIP assay, Western blot assay |
| Enhancer experiment description: | Taken all together, we confirmed that lncRNA PRNCR1 upregulates HEY2 to promote tumor progression in NSCLC by competitively binding miR-448. |
About Target gene
| Target gene : | PRNCR1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Taken all together, we confirmed that lncRNA PRNCR1 upregulates HEY2 to promote tumor progression in NSCLC by competitively binding miR-448. ;Taken all together, we confirmed that lncRNA PRNCR1 upregulates HEY2 to promote tumor progression in NSCLC by competitively binding miR-448. |
About TF
| TF name : | HEY2 |
| TF experiment: | Cell transfection,RNA isolation,qRT-PCR analysi, Cell proliferation assays, Transwell assays,Luciferase reporter analysis,RIP assay, Western blot assay |
| TF experiment description: | Taken all together, we confirmed that lncRNA PRNCR1 upregulates HEY2 to promote tumor progression in NSCLC by competitively binding miR-448. ;Taken all together, we confirmed that lncRNA PRNCR1 upregulates HEY2 to promote tumor progression in NSCLC by competitively binding miR-448. |
About Function
| Enhancer function : | Taken all together, we confirmed that lncRNA PRNCR1 upregulates HEY2 to promote tumor progression in NSCLC by competitively binding miR-448. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Taken all together, we confirmed that lncRNA PRNCR1 upregulates HEY2 to promote tumor progression in NSCLC by competitively binding miR-448. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| HEY2 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | reactome | 57 |
| HEY2 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | reactome | 57 |
| HEY2 | Notch-mediated HES/HEY network | pid | 48 |
| HEY2 | Notch | netpath | 76 |
| HEY2 | NOTCH1 Intracellular Domain Regulates Transcription | reactome | 47 |
| HEY2 | p73 transcription factor network | pid | 80 |
| HEY2 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
| HEY2 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene