About Enhancer
| Enhancer ID: |
E_01_0696 |
| Species: |
human |
| Position :
|
chr4:74442566-74444566
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
Colorectal cancer |
| Pubmed ID: |
30252132
|
| Enhancer experiment: |
RNA isolation and Real-time PCR analysis,Methylation analysis,Luciferase reporter analysis,immunohistochemistry |
| Enhancer experiment description: |
Expression of the epidermal growth factor ligands amphiregulin (AREG) and epiregulin (EREG) is positively correlated with a response to EGFR-targeted therapies in colorectal cancer. |
About Target gene
| Target gene : |
AREG,EREG |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
Expression of the epidermal growth factor ligands amphiregulin (AREG) and epiregulin (EREG) is positively correlated with a response to EGFR-targeted therapies in colorectal cancer. ;Expression of the epidermal growth factor ligands amphiregulin (AREG) and epiregulin (EREG) is positively correlated with a response to EGFR-targeted therapies in colorectal cancer. |
About TF
| TF name : |
-- |
| TF experiment: |
RNA isolation and Real-time PCR analysis,Methylation analysis,Luciferase reporter analysis,immunohistochemistry |
| TF experiment description: |
Expression of the epidermal growth factor ligands amphiregulin (AREG) and epiregulin (EREG) is positively correlated with a response to EGFR-targeted therapies in colorectal cancer. ;Expression of the epidermal growth factor ligands amphiregulin (AREG) and epiregulin (EREG) is positively correlated with a response to EGFR-targeted therapies in colorectal cancer. |
About Function
| Enhancer function : |
Expression of the epidermal growth factor ligands amphiregulin (AREG) and epiregulin (EREG) is positively correlated with a response to EGFR-targeted therapies in colorectal cancer. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
Expression of the epidermal growth factor ligands amphiregulin (AREG) and epiregulin (EREG) is positively correlated with a response to EGFR-targeted therapies in colorectal cancer. |
About SNP
Upstream Pathway Annotation of TF
| GeneName |
Pathway Name |
Source |
Gene Number |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs