About Enhancer
| Enhancer ID: | E_01_0712 |
| Species: | human |
| Position : | chr7:117284540-117286540   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Liver injury |
| Pubmed ID: | 29415998 |
| Enhancer experiment: | Quantitative real-time PCR,Western blot,Chromatin immunoprecipitation (ChIP) assays,Bisulfite sequencing,RNA interference |
| Enhancer experiment description: | In conclusion, our study showed that Hcy activates autophagy by inhibition of CFTR expression via interaction between H3K27me3 and DNA methylation in the mouse liver. These findings provide new insight into the mechanism of Hcyinduced autophagy in liver injury |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | In conclusion, our study showed that Hcy activates autophagy by inhibition of CFTR expression via interaction between H3K27me3 and DNA methylation in the mouse liver. These findings provide new insight into the mechanism of Hcyinduced autophagy in liver injury |
About TF
| TF name : | CFTR |
| TF experiment: | Quantitative real-time PCR,Western blot,Chromatin immunoprecipitation (ChIP) assays,Bisulfite sequencing,RNA interference |
| TF experiment description: | In conclusion, our study showed that Hcy activates autophagy by inhibition of CFTR expression via interaction between H3K27me3 and DNA methylation in the mouse liver. These findings provide new insight into the mechanism of Hcyinduced autophagy in liver injury |
About Function
| Enhancer function : | In conclusion, our study showed that Hcy activates autophagy by inhibition of CFTR expression via interaction between H3K27me3 and DNA methylation in the mouse liver. These findings provide new insight into the mechanism of Hcyinduced autophagy in liver injury |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
In conclusion, our study showed that Hcy activates autophagy by inhibition of CFTR expression via interaction between H3K27me3 and DNA methylation in the mouse liver. These findings provide new insight into the mechanism of Hcyinduced autophagy in liver injury |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CFTR | ABC-family proteins mediated transport | reactome | 24 |
| CFTR | Gastric acid secretion | kegg | 68 |
| CFTR | Pancreatic secretion | kegg | 97 |
| CFTR | Vibrio cholerae infection | kegg | 51 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene