About Enhancer

Enhancer ID: E_01_0726
Species: human
Position : chr3:119521370-119523370
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Chronic inflammation
Pubmed ID:  30201991
Enhancer experiment: RNA SEQ, chip SEQ, qPCR, chip qPCR, flow cytometry
Enhancer experiment description: For example, CTLA-4 can inhibit T cell activation intrinsically by outcompeting CD28 for binding to CD80 and CD86, while PD-1 engagement by PD-L1 or PD-L2 triggers an inhibitory signal.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: For example, CTLA-4 can inhibit T cell activation intrinsically by outcompeting CD28 for binding to CD80 and CD86, while PD-1 engagement by PD-L1 or PD-L2 triggers an inhibitory signal. ;For example, CTLA-4 can inhibit T cell activation intrinsically by outcompeting CD28 for binding to CD80 and CD86, while PD-1 engagement by PD-L1 or PD-L2 triggers an inhibitory signal.

About TF

TF name : CD80CD86
TF experiment: RNA-seq,ChIP-seq,qPCR, ChIP-qPCR,?????
TF experiment description: For example, CTLA-4 can inhibit T cell activation intrinsically by outcompeting CD28 for binding to CD80 and CD86, while PD-1 engagement by PD-L1 or PD-L2 triggers an inhibitory signal. ;For example, CTLA-4 can inhibit T cell activation intrinsically by outcompeting CD28 for binding to CD80 and CD86, while PD-1 engagement by PD-L1 or PD-L2 triggers an inhibitory signal.

About Function

Enhancer function : For example, CTLA-4 can inhibit T cell activation intrinsically by outcompeting CD28 for binding to CD80 and CD86, while PD-1 engagement by PD-L1 or PD-L2 triggers an inhibitory signal.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 For example, CTLA-4 can inhibit T cell activation intrinsically by outcompeting CD28 for binding to CD80 and CD86, while PD-1 engagement by PD-L1 or PD-L2 triggers an inhibitory signal.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
CD80 CD28 co-stimulation reactome 9
CD80 CD28 dependent PI3K/Akt signaling reactome 22
CD80 CD28 dependent Vav1 pathway reactome 12
CD80 CD28 signaling ( CD4 T cell receptor signaling (NF-kB cascade) ) inoh 14
CD80 CD28 signaling ( CD4 T cell receptor signaling ) inoh 14
CD80 Constitutive Signaling by Aberrant PI3K in Cancer reactome 61
CD80 CTLA4 inhibitory signaling reactome 22
CD80 Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin) ( GPCR signaling (pertussis toxin) ) inoh 228
CD80 Heterotrimeric GPCR signaling pathway (through G alpha q, PLC beta and ERK cascade) ( GPCR signaling (G alpha q) ) inoh 239
CD80 Heterotrimeric GPCR signaling pathway (through G alpha s ACs Epac BRaf and ERKcascade) ( GPCR signaling (G alpha s, Epac and ERK) ) inoh 237
CD80 Heterotrimeric GPCR signaling pathway (through_G alpha s_ACs_PKA_BRaf_and_ERKcascade)(canonical) ( GPCR signaling (G alpha s, PKA and ERK) ) inoh 227
CD80 Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through G alpha i, adenylate cyclase and cAMP) ( GPCR signaling (G alpha i) ) inoh 228
CD80 Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through_G_alpha_s,_cholera_toxin,_adenylate_cyclase_and_cAMP) ( GPCR signaling (cholera toxin) ) inoh 227
CD80 IL12 signaling mediated by STAT4 pid 33
CD80 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling reactome 83
CD80 PIP3 activates AKT signaling reactome 81
CD80 T cell activation panther 60
CD80 TCR netpath 261
CD80 TCR signaling in nave CD4+ T cells pid 69
CD80 TCR signaling in nave CD8+ T cells pid 56
CD80 Cell adhesion molecules (CAMs) kegg 133
CD80 Toll-like receptor signaling pathway kegg 100
CD80 Intestinal immune network for IgA production kegg 48
CD80 Type I diabetes mellitus kegg 42
CD80 Autoimmune thyroid disease kegg 52
CD80 Systemic lupus erythematosus kegg 136
CD80 Allograft rejection kegg 37
CD80 Graft-versus-host disease kegg 33
CD80 Viral myocarditis kegg 66
CD80 Hs_Allograft_Rejection_WP2328_90020 wikipathways 12
CD86 CD28 co-stimulation reactome 9
CD86 CD28 dependent PI3K/Akt signaling reactome 22
CD86 CD28 dependent Vav1 pathway reactome 12
CD86 CD28 signaling ( CD4 T cell receptor signaling (NF-kB cascade) ) inoh 14
CD86 CD28 signaling ( CD4 T cell receptor signaling ) inoh 14
CD86 Constitutive Signaling by Aberrant PI3K in Cancer reactome 61
CD86 CTLA4 inhibitory signaling reactome 22
CD86 Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin) ( GPCR signaling (pertussis toxin) ) inoh 228
CD86 Heterotrimeric GPCR signaling pathway (through G alpha q, PLC beta and ERK cascade) ( GPCR signaling (G alpha q) ) inoh 239
CD86 Heterotrimeric GPCR signaling pathway (through G alpha s ACs Epac BRaf and ERKcascade) ( GPCR signaling (G alpha s, Epac and ERK) ) inoh 237
CD86 Heterotrimeric GPCR signaling pathway (through_G alpha s_ACs_PKA_BRaf_and_ERKcascade)(canonical) ( GPCR signaling (G alpha s, PKA and ERK) ) inoh 227
CD86 Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through G alpha i, adenylate cyclase and cAMP) ( GPCR signaling (G alpha i) ) inoh 228
CD86 Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through_G_alpha_s,_cholera_toxin,_adenylate_cyclase_and_cAMP) ( GPCR signaling (cholera toxin) ) inoh 227
CD86 IL12 signaling mediated by STAT4 pid 33
CD86 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling reactome 83
CD86 PIP3 activates AKT signaling reactome 81
CD86 T cell activation panther 60
CD86 TCR netpath 261
CD86 TCR signaling in nave CD4+ T cells pid 69
CD86 TCR signaling in nave CD8+ T cells pid 56
CD86 Cell adhesion molecules (CAMs) kegg 133
CD86 Toll-like receptor signaling pathway kegg 100
CD86 Intestinal immune network for IgA production kegg 48
CD86 Type I diabetes mellitus kegg 42
CD86 Autoimmune thyroid disease kegg 52
CD86 Systemic lupus erythematosus kegg 136
CD86 Allograft rejection kegg 37
CD86 Graft-versus-host disease kegg 33
CD86 Viral myocarditis kegg 66

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs