About Enhancer
| Enhancer ID: | E_01_0736 |
| Species: | human |
| Position : | chr20:38343789-38345789   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Degenerative disc disease, inflammation, neurodegenerative disease, type 2 diabetes, rheumatoid arthritis |
| Pubmed ID: | 30174670 |
| Enhancer experiment: | Enzyme-Linked Immunosorbent Assay,Metabolic Activity Assay (MTT),RT-qPCR |
| Enhancer experiment description: | LBP can raise both from IVD-induced damage of dorsal root ganglions (DRG) and from nociceptive stimulation of DRGs by molecules released from the degenerated IVD (7 9). Indeed, severity of DDD correlates with increased expression of inflammation mediators/markers in the IVD tissue (10), including interleukin-1 beta (IL-1?) (11), tumor necrosis factor-alpha (TNF-?) (12), interleukin-6 (IL-6), and interleukin-8 (IL-8) (13). |
About Target gene
| Target gene : | LBP,IVD |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | LBP can raise both from IVD-induced damage of dorsal root ganglions (DRG) and from nociceptive stimulation of DRGs by molecules released from the degenerated IVD (7 9). Indeed, severity of DDD correlates with increased expression of inflammation mediators/markers in the IVD tissue (10), including interleukin-1 beta (IL-1?) (11), tumor necrosis factor-alpha (TNF-?) (12), interleukin-6 (IL-6), and interleukin-8 (IL-8) (13).;LBP can raise both from IVD-induced damage of dorsal root ganglions (DRG) and from nociceptive stimulation of DRGs by molecules released from the degenerated IVD (7 9). Indeed, severity of DDD correlates with increased expression of inflammation mediators/markers in the IVD tissue (10), including interleukin-1 beta (IL-1?) (11), tumor necrosis factor-alpha (TNF-?) (12), interleukin-6 (IL-6), and interleukin-8 (IL-8) (13). |
About TF
| TF name : | -- |
| TF experiment: | Enzyme-Linked Immunosorbent Assay,Metabolic Activity Assay (MTT),RT-qPCR |
| TF experiment description: | LBP can raise both from IVD-induced damage of dorsal root ganglions (DRG) and from nociceptive stimulation of DRGs by molecules released from the degenerated IVD (7 9). Indeed, severity of DDD correlates with increased expression of inflammation mediators/markers in the IVD tissue (10), including interleukin-1 beta (IL-1?) (11), tumor necrosis factor-alpha (TNF-?) (12), interleukin-6 (IL-6), and interleukin-8 (IL-8) (13).;LBP can raise both from IVD-induced damage of dorsal root ganglions (DRG) and from nociceptive stimulation of DRGs by molecules released from the degenerated IVD (7 9). Indeed, severity of DDD correlates with increased expression of inflammation mediators/markers in the IVD tissue (10), including interleukin-1 beta (IL-1?) (11), tumor necrosis factor-alpha (TNF-?) (12), interleukin-6 (IL-6), and interleukin-8 (IL-8) (13). |
About Function
| Enhancer function : | LBP can raise both from IVD-induced damage of dorsal root ganglions (DRG) and from nociceptive stimulation of DRGs by molecules released from the degenerated IVD (7 9). Indeed, severity of DDD correlates with increased expression of inflammation mediators/markers in the IVD tissue (10), including interleukin-1 beta (IL-1?) (11), tumor necrosis factor-alpha (TNF-?) (12), interleukin-6 (IL-6), and interleukin-8 (IL-8) (13). |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
LBP can raise both from IVD-induced damage of dorsal root ganglions (DRG) and from nociceptive stimulation of DRGs by molecules released from the degenerated IVD (7 9). Indeed, severity of DDD correlates with increased expression of inflammation mediators/markers in the IVD tissue (10), including interleukin-1 beta (IL-1?) (11), tumor necrosis factor-alpha (TNF-?) (12), interleukin-6 (IL-6), and interleukin-8 (IL-8) (13). |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene