About Enhancer

Enhancer ID: E_01_0755
Species: human
Position : chr1:212033036-212035036
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Hepatocellular carcinoma
Pubmed ID:  30127913
Enhancer experiment: RT qPCR, statistical analysis
Enhancer experiment description: The present study suggested that DTL, DUSP1, NFKBIA and SOCS2 may be potential biomarkers of HCC, and the tumor protein p53 signaling , forkhead box O1 signaling and metabolic pathways may serve roles in the pathogenesis of HCC.

About Target gene

Target gene : DTL,DUSP1(CL100,HVH1,MKP-1,MKP1,PTPN10),SOCS2
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: The present study suggested that DTL, DUSP1, NFKBIA and SOCS2 may be potential biomarkers of HCC, and the tumor protein p53 signaling , forkhead box O1 signaling and metabolic pathways may serve roles in the pathogenesis of HCC.;The present study suggested that DTL, DUSP1, NFKBIA and SOCS2 may be potential biomarkers of HCC, and the tumor protein p53 signaling , forkhead box O1 signaling and metabolic pathways may serve roles in the pathogenesis of HCC.;The present study suggested that DTL, DUSP1, NFKBIA and SOCS2 may be potential biomarkers of HCC, and the tumor protein p53 signaling , forkhead box O1 signaling and metabolic pathways may serve roles in the pathogenesis of HCC.;The present study suggested that DTL, DUSP1, NFKBIA and SOCS2 may be potential biomarkers of HCC, and the tumor protein p53 signaling , forkhead box O1 signaling and metabolic pathways may serve roles in the pathogenesis of HCC.

About TF

TF name : NFKBIA
TF experiment: RT-qPCR,????
TF experiment description: The present study suggested that DTL, DUSP1, NFKBIA and SOCS2 may be potential biomarkers of HCC, and the tumor protein p53 signaling , forkhead box O1 signaling and metabolic pathways may serve roles in the pathogenesis of HCC.;The present study suggested that DTL, DUSP1, NFKBIA and SOCS2 may be potential biomarkers of HCC, and the tumor protein p53 signaling , forkhead box O1 signaling and metabolic pathways may serve roles in the pathogenesis of HCC.;The present study suggested that DTL, DUSP1, NFKBIA and SOCS2 may be potential biomarkers of HCC, and the tumor protein p53 signaling , forkhead box O1 signaling and metabolic pathways may serve roles in the pathogenesis of HCC.;The present study suggested that DTL, DUSP1, NFKBIA and SOCS2 may be potential biomarkers of HCC, and the tumor protein p53 signaling , forkhead box O1 signaling and metabolic pathways may serve roles in the pathogenesis of HCC.

About Function

Enhancer function : The present study suggested that DTL, DUSP1, NFKBIA and SOCS2 may be potential biomarkers of HCC, and the tumor protein p53 signaling , forkhead box O1 signaling and metabolic pathways may serve roles in the pathogenesis of HCC.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 The present study suggested that DTL, DUSP1, NFKBIA and SOCS2 may be potential biomarkers of HCC, and the tumor protein p53 signaling , forkhead box O1 signaling and metabolic pathways may serve roles in the pathogenesis of HCC.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
NFKBIA Activation of NF-kappaB in B cells reactome 66
NFKBIA Apoptosis signaling pathway panther 104
NFKBIA Atypical NF-kappaB pathway pid 14
NFKBIA Aurora A signaling pid 33
NFKBIA B cell activation panther 52
NFKBIA BCR netpath 161
NFKBIA BCR signaling pathway pid 70
NFKBIA Canonical NF-kappaB pathway pid 24
NFKBIA CD40/CD40L signaling pid 36
NFKBIA Ceramide signaling pathway pid 49
NFKBIA CLEC7A (Dectin-1) signaling reactome 78
NFKBIA Downstream TCR signaling reactome 101
NFKBIA FCERI mediated NF-kB activation reactome 88
NFKBIA HIV-1 Nef: Negative effector of Fas and TNF-alpha pid 33
NFKBIA IkBA variant leads to EDA-ID reactome 7
NFKBIA IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) reactome 8
NFKBIA IKK-NF-kappaB cascade ( B cell receptor signaling ) inoh 8
NFKBIA IKK-NF-kappaB cascade ( CD4 T cell receptor signaling (NF-kB cascade) ) inoh 8
NFKBIA IKK-NF-kappaB cascade ( CD4 T cell receptor signaling ) inoh 8
NFKBIA IKK-NFkB cascade ( TNFR1 signaling pathway ) inoh 11
NFKBIA IL1 netpath 69
NFKBIA IL23-mediated signaling events pid 37
NFKBIA IL4 netpath 75
NFKBIA IL5 netpath 59
NFKBIA IL6 netpath 85
NFKBIA Intracellular Signalling Through Adenosine Receptor A2a and Adenosine smpdb 37
NFKBIA Intracellular Signalling Through Adenosine Receptor A2b and Adenosine smpdb 38
NFKBIA Kaposi sarcoma-associated herpesvirus mirtarbase 13
NFKBIA Leptin netpath 98
NFKBIA LPA receptor mediated events pid 65
NFKBIA NF-kB is activated and signals survival reactome 13
NFKBIA NF-kB signaling ( Toll-like receptor signaling pathway (trough NF-kappaB) ) inoh 12
NFKBIA Osteopontin-mediated events pid 32
NFKBIA Prolactin netpath 105
NFKBIA RANKL netpath 84
NFKBIA RIP-mediated NFkB activation via ZBP1 reactome 21
NFKBIA Signaling events mediated by HDAC Class I pid 89
NFKBIA T cell activation panther 60
NFKBIA TAK1 activates NFkB by phosphorylation and activation of IKKs complex reactome 26
NFKBIA TCR netpath 261
NFKBIA TGF_beta_Receptor netpath 220
NFKBIA TNFalpha netpath 274
NFKBIA Toll receptor signaling pathway panther 44
NFKBIA TRAF6 mediated NF-kB activation reactome 24
NFKBIA TSH netpath 82
NFKBIA TSLP netpath 24
NFKBIA TWEAK netpath 35
NFKBIA Chemokine signaling pathway kegg 187
NFKBIA Apoptosis kegg 88
NFKBIA Toll-like receptor signaling pathway kegg 100
NFKBIA NOD-like receptor signaling pathway kegg 60
NFKBIA RIG-I-like receptor signaling pathway kegg 71
NFKBIA Cytosolic DNA-sensing pathway kegg 56
NFKBIA T cell receptor signaling pathway kegg 105
NFKBIA B cell receptor signaling pathway kegg 70
NFKBIA Neurotrophin signaling pathway kegg 126
NFKBIA Adipocytokine signaling pathway kegg 65
NFKBIA Epithelial cell signaling in Helicobacter pylori infection kegg 67
NFKBIA Shigellosis kegg 60
NFKBIA Leishmaniasis kegg 71
NFKBIA Chagas disease kegg 103
NFKBIA Toxoplasmosis kegg 131
NFKBIA Hepatitis C kegg 134
NFKBIA Pathways in cancer kegg 321
NFKBIA Prostate cancer kegg 85
NFKBIA Chronic myeloid leukemia kegg 69
NFKBIA Small cell lung cancer kegg 83
NFKBIA Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 wikipathways 41
NFKBIA Hs_Nucleotide-binding_Oligomerization_Domain_(NOD)_pathway_WP1433_86035 wikipathways 37
NFKBIA Hs_Apoptosis_Modulation_and_Signaling_WP1772_91293 wikipathways 71
NFKBIA Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
NFKBIA Hs_Inflammatory_Response_Pathway_WP453_80206 wikipathways 6
NFKBIA Hs_ATM_Signaling_Pathway_WP2516_90247 wikipathways 32
NFKBIA Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 wikipathways 44
NFKBIA Hs_TNF_related_weak_inducer_of_apoptosis_(TWEAK)_Signaling_Pathway_WP2036_89910 wikipathways 27
NFKBIA Hs_Vitamin_B12_Metabolism_WP1533_85340 wikipathways 33
NFKBIA Hs_T-Cell_Receptor_and_Co-stimulatory_Signaling_WP2583_86147 wikipathways 11
NFKBIA Hs_Regulation_of_toll-like_receptor_signaling_pathway_WP1449_81172 wikipathways 47
NFKBIA Hs_Toll-like_Receptor_Signaling_Pathway_WP75_83867 wikipathways 17
NFKBIA Hs_TNF_alpha_Signaling_Pathway_WP231_89895 wikipathways 61
NFKBIA Hs_AGE-RAGE_pathway_WP2324_89798 wikipathways 27
NFKBIA Hs_IL-4_Signaling_Pathway_WP395_89828 wikipathways 41
NFKBIA Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 wikipathways 80
NFKBIA Hs_T-Cell_antigen_Receptor_(TCR)_Signaling_Pathway_WP69_89937 wikipathways 60
NFKBIA Hs_IL-1_signaling_pathway_WP195_89932 wikipathways 34
NFKBIA Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 wikipathways 26
NFKBIA Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 wikipathways 71

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs