About Enhancer
| Enhancer ID: | E_01_0769 |
| Species: | human |
| Position : | chr3:133743162-133745162   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 30097539 |
| Enhancer experiment: | ChIP-seq,DNase-seq ,PCR,RNA-seq |
| Enhancer experiment description: | Glucocorticoids are potent steroid hormones that regulate immunity and metabolism by activating the transcription factor (TF) activity of glucocorticoid receptor (GR). At these sites, GR also commonly cobinds with certain pioneer factors, such as AP-1 TFs (Biddie et al. 2011) and CEBPB (Grntved et al. 2013), which are so designated for their ability to bind sequence motifs in condensed chromatin and to remodel chromatin to increase accessibility (Zaret and Carroll 2011). |
About Target gene
| Target gene : | TF |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Glucocorticoids are potent steroid hormones that regulate immunity and metabolism by activating the transcription factor (TF) activity of glucocorticoid receptor (GR). At these sites, GR also commonly cobinds with certain pioneer factors, such as AP-1 TFs (Biddie et al. 2011) and CEBPB (Grntved et al. 2013), which are so designated for their ability to bind sequence motifs in condensed chromatin and to remodel chromatin to increase accessibility (Zaret and Carroll 2011). |
About TF
| TF name : | -- |
| TF experiment: | ChIP-seq,DNase-seq ,PCR,RNA-seq |
| TF experiment description: | Glucocorticoids are potent steroid hormones that regulate immunity and metabolism by activating the transcription factor (TF) activity of glucocorticoid receptor (GR). At these sites, GR also commonly cobinds with certain pioneer factors, such as AP-1 TFs (Biddie et al. 2011) and CEBPB (Grntved et al. 2013), which are so designated for their ability to bind sequence motifs in condensed chromatin and to remodel chromatin to increase accessibility (Zaret and Carroll 2011). |
About Function
| Enhancer function : | Glucocorticoids are potent steroid hormones that regulate immunity and metabolism by activating the transcription factor (TF) activity of glucocorticoid receptor (GR). At these sites, GR also commonly cobinds with certain pioneer factors, such as AP-1 TFs (Biddie et al. 2011) and CEBPB (Grntved et al. 2013), which are so designated for their ability to bind sequence motifs in condensed chromatin and to remodel chromatin to increase accessibility (Zaret and Carroll 2011). |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Glucocorticoids are potent steroid hormones that regulate immunity and metabolism by activating the transcription factor (TF) activity of glucocorticoid receptor (GR). At these sites, GR also commonly cobinds with certain pioneer factors, such as AP-1 TFs (Biddie et al. 2011) and CEBPB (Grntved et al. 2013), which are so designated for their ability to bind sequence motifs in condensed chromatin and to remodel chromatin to increase accessibility (Zaret and Carroll 2011). |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene