About Enhancer
| Enhancer ID: | E_01_0790 |
| Species: | human |
| Position : | chr4:25645137-25647137   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Colorectal, ovarian, breast, gastric, lung |
| Pubmed ID: | 30038060 |
| Enhancer experiment: | Quantitative real-time RT-PCR, Western blot, MTT assay, TUNEL assay, FACS analysis, statistical analysis, gene knockdown |
| Enhancer experiment description: | Here, we indicated that SLC34A2 expression was markedly increased in SW480 and HT29 cell line cells compared with that in normal colorectal epithelial cell line cells. We demonstrated that SLC34A2 induced EZH2 expression and activated its promoter activity. |
About Target gene
| Target gene : | SLC34A2 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Here, we indicated that SLC34A2 expression was markedly increased in SW480 and HT29 cell line cells compared with that in normal colorectal epithelial cell line cells. We demonstrated that SLC34A2 induced EZH2 expression and activated its promoter activity.;Here, we indicated that SLC34A2 expression was markedly increased in SW480 and HT29 cell line cells compared with that in normal colorectal epithelial cell line cells. We demonstrated that SLC34A2 induced EZH2 expression and activated its promoter activity. |
About TF
| TF name : | EZH2(ENX-1,ENX1b,KMT6,KMT6A,WVS,WVS2,EZH2) |
| TF experiment: | Quantitative real-time RT-PCR,Western blot,MTT assay,TUNEL assay,FACS??,????,???? |
| TF experiment description: | Here, we indicated that SLC34A2 expression was markedly increased in SW480 and HT29 cell line cells compared with that in normal colorectal epithelial cell line cells. We demonstrated that SLC34A2 induced EZH2 expression and activated its promoter activity.;Here, we indicated that SLC34A2 expression was markedly increased in SW480 and HT29 cell line cells compared with that in normal colorectal epithelial cell line cells. We demonstrated that SLC34A2 induced EZH2 expression and activated its promoter activity. |
About Function
| Enhancer function : | Here, we indicated that SLC34A2 expression was markedly increased in SW480 and HT29 cell line cells compared with that in normal colorectal epithelial cell line cells. We demonstrated that SLC34A2 induced EZH2 expression and activated its promoter activity. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Here, we indicated that SLC34A2 expression was markedly increased in SW480 and HT29 cell line cells compared with that in normal colorectal epithelial cell line cells. We demonstrated that SLC34A2 induced EZH2 expression and activated its promoter activity. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| EZH2 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| EZH2 | Oxidative Stress Induced Senescence | reactome | 120 |
| EZH2 | PKMTs methylate histone lysines | reactome | 64 |
| EZH2 | PRC2 methylates histones and DNA | reactome | 71 |
| EZH2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| EZH2 | Hs_Interactome_of_polycomb_repressive_complex_2_(PRC2)_WP2916_88672 | wikipathways | 15 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene