About Enhancer

Enhancer ID: E_01_0841
Species: human
Position : chr10:112947297-112949297
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Diabetes
Pubmed ID:  33257854
Enhancer experiment: Cell directed differentiation versus hESCs, cell directed differentiation versus hESCs, fluorescence quantitative polymerase chain reaction, sgRNA cargo, gene knockdown, GSEA functional enrichment analysis, transient transcription factor motif enrichment analysis, two wave gene analysis
Enhancer experiment description: We also identify a stage-specific enhancer in the TCF7L2 diabetes GWAS locus that drives a transient wave of gene expression in pancreatic progenitors.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: We also identify a stage-specific enhancer in the TCF7L2 diabetes GWAS locus that drives a transient wave of gene expression in pancreatic progenitors.

About TF

TF name : TCF7L2
TF experiment: ???????hESCs????????hESCs????????????sgRNA-CARGO????? ?GSEA??????????????????????????
TF experiment description: We also identify a stage-specific enhancer in the TCF7L2 diabetes GWAS locus that drives a transient wave of gene expression in pancreatic progenitors.

About Function

Enhancer function : We also identify a stage-specific enhancer in the TCF7L2 diabetes GWAS locus that drives a transient wave of gene expression in pancreatic progenitors.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 We also identify a stage-specific enhancer in the TCF7L2 diabetes GWAS locus that drives a transient wave of gene expression in pancreatic progenitors.

About SNP

SNP ID: rs180988137,rs78025551,rs7903146

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
TCF7L2 Alzheimer disease-presenilin pathway panther 98
TCF7L2 Angiogenesis panther 141
TCF7L2 AP-1 transcription factor network pid 71
TCF7L2 Binding of TCF/LEF:CTNNB1 to target gene promoters reactome 7
TCF7L2 Ca2+ pathway reactome 62
TCF7L2 Cadherin signaling pathway panther 147
TCF7L2 Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram ) inoh 56
TCF7L2 Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram ) inoh 56
TCF7L2 Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) inoh 56
TCF7L2 Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) inoh 56
TCF7L2 Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 56
TCF7L2 Deactivation of the beta-catenin transactivating complex reactome 42
TCF7L2 Formation of the beta-catenin:TCF transactivating complex reactome 88
TCF7L2 ID netpath 38
TCF7L2 Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) inoh 49
TCF7L2 Regulation of nuclear beta catenin signaling and target gene transcription pid 80
TCF7L2 Repression of WNT target genes reactome 14
TCF7L2 Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) inoh 47
TCF7L2 Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) inoh 47
TCF7L2 Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) inoh 47
TCF7L2 Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) inoh 47
TCF7L2 Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 47
TCF7L2 Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) inoh 47
TCF7L2 Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 19
TCF7L2 Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) inoh 8
TCF7L2 Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) inoh 8
TCF7L2 Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) inoh 8
TCF7L2 Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) inoh 8
TCF7L2 Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 8
TCF7L2 Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) inoh 8
TCF7L2 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) reactome 20
TCF7L2 Wnt netpath 118
TCF7L2 Wnt signaling pathway panther 250
TCF7L2 Wnt signaling pathway kegg 135
TCF7L2 Adherens junction kegg 70
TCF7L2 Melanogenesis kegg 100
TCF7L2 Pathways in cancer kegg 321
TCF7L2 Colorectal cancer kegg 63
TCF7L2 Endometrial cancer kegg 52
TCF7L2 Prostate cancer kegg 85
TCF7L2 Acute myeloid leukemia kegg 53
TCF7L2 Arrhythmogenic right ventricular cardiomyopathy (ARVC) kegg 71

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs