About Enhancer

Enhancer ID: E_01_0845
Species: human
Position : chr2:112827574-112829574
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Be senile
Pubmed ID:  33247104
Enhancer experiment: Dna-fish, immunofluorescence, chip SEQ, quantitative reverse transcription polymerase chain reaction, Hi-C and capture Hi-C, chip SEQ analysis, ribonucleic acid sequence analysis
Enhancer experiment description: RAS-induced de novo cohesin peaks are transcription-dependent and enriched for senescence-associated genes, exemplified by IL1B, where de novo cohesin binding is involved in new loop formation.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: RAS-induced de novo cohesin peaks are transcription-dependent and enriched for senescence-associated genes, exemplified by IL1B, where de novo cohesin binding is involved in new loop formation.

About TF

TF name : IL1B
TF experiment: DNA-FISH??????ChIP-seq??????-???????Hi-C ? Capture Hi-C?ChIP-seq ???????????
TF experiment description: RAS-induced de novo cohesin peaks are transcription-dependent and enriched for senescence-associated genes, exemplified by IL1B, where de novo cohesin binding is involved in new loop formation.

About Function

Enhancer function : RAS-induced de novo cohesin peaks are transcription-dependent and enriched for senescence-associated genes, exemplified by IL1B, where de novo cohesin binding is involved in new loop formation.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 RAS-induced de novo cohesin peaks are transcription-dependent and enriched for senescence-associated genes, exemplified by IL1B, where de novo cohesin binding is involved in new loop formation.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
IL1B Budesonide inhibits the reaction [IL1B protein results in increased acetylation of HIST4H4 protein] ctd 15
IL1B Cellular roles of Anthrax toxin pid 25
IL1B CLEC7A/inflammasome pathway reactome 6
IL1B Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin) ( GPCR signaling (pertussis toxin) ) inoh 228
IL1B Heterotrimeric GPCR signaling pathway (through G alpha q, PLC beta and ERK cascade) ( GPCR signaling (G alpha q) ) inoh 239
IL1B Heterotrimeric GPCR signaling pathway (through G alpha s ACs Epac BRaf and ERKcascade) ( GPCR signaling (G alpha s, Epac and ERK) ) inoh 237
IL1B Heterotrimeric GPCR signaling pathway (through_G alpha s_ACs_PKA_BRaf_and_ERKcascade)(canonical) ( GPCR signaling (G alpha s, PKA and ERK) ) inoh 227
IL1B Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through G alpha i, adenylate cyclase and cAMP) ( GPCR signaling (G alpha i) ) inoh 228
IL1B Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through_G_alpha_s,_cholera_toxin,_adenylate_cyclase_and_cAMP) ( GPCR signaling (cholera toxin) ) inoh 227
IL1B IFN-gamma pathway pid 43
IL1B IL-1 signaling pathway (through p38 cascade) ( IL-1 signaling pathway (through p38 cascade) ) inoh 14
IL1B IL-1_signaling(through_IKK-NFkB_cascade)(canonical) ( IL-1 signaling pathway (through NF-kappaB) ) inoh 15
IL1B IL-1_signaling(through_JNK_cascade)(canonical) ( IL-1 signaling pathway (through JNK cascade) ) inoh 14
IL1B IL1-mediated signaling events pid 34
IL1B IL1 netpath 69
IL1B IL12-mediated signaling events pid 62
IL1B IL23-mediated signaling events pid 37
IL1B IL27-mediated signaling events pid 26
IL1B Interleukin-1 processing reactome 7
IL1B Interleukin-1 signaling reactome 31
IL1B JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 97
IL1B Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, JNK cascade) ( Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, JNK cascade) ) inoh 15
IL1B Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK, TAK1 and IKK-NF-kappaB cascade)(Canonical) ( Toll-like receptor signaling pathway (trough NF-kappaB) ) inoh 19
IL1B MAPK signaling pathway kegg 264
IL1B Cytokine-cytokine receptor interaction kegg 213
IL1B Apoptosis kegg 88
IL1B Toll-like receptor signaling pathway kegg 100
IL1B NOD-like receptor signaling pathway kegg 60
IL1B Cytosolic DNA-sensing pathway kegg 56
IL1B Type I diabetes mellitus kegg 42
IL1B Alzheimer's disease kegg 167
IL1B Prion diseases kegg 34
IL1B Leishmaniasis kegg 71
IL1B Chagas disease kegg 103
IL1B Malaria kegg 50
IL1B Amoebiasis kegg 103
IL1B Graft-versus-host disease kegg 33
IL1B Hs_Leptin_signaling_pathway_WP2034_89856 wikipathways 37
IL1B Hs_Nucleotide-binding_Oligomerization_Domain_(NOD)_pathway_WP1433_86035 wikipathways 37
IL1B Hs_Senescence_and_Autophagy_in_Cancer_WP615_81193 wikipathways 62
IL1B Hs_Selenium_Metabolism_and_Selenoproteins_WP28_71888 wikipathways 9
IL1B Hs_Folate_Metabolism_WP176_85063 wikipathways 33
IL1B Hs_Vitamin_B12_Metabolism_WP1533_85340 wikipathways 33
IL1B Hs_Lung_fibrosis_WP3624_91475 wikipathways 23
IL1B Hs_Monoamine_Transport_WP727_90193 wikipathways 24
IL1B Hs_IL1_and_megakaryocytes_in_obesity_WP2865_88662 wikipathways 5
IL1B Hs_Serotonin_Transporter_Activity_WP1455_89635 wikipathways 9
IL1B Hs_Selenium_Micronutrient_Network_WP15_88908 wikipathways 35

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs