About Enhancer
| Enhancer ID: | E_01_0868 |
| Species: | human |
| Position : | chr5:138462973-138464973   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Gastric cancer |
| Pubmed ID: | 33145887 |
| Enhancer experiment: | RT qPCR analysis, cell transfection, RNA immunoprecipitation (RIP), chromatin immunoprecipitation test (chip), subcellular fractionation, and fluorescence in situ hybridization (FISH) assay |
| Enhancer experiment description: | EGR1?activated linc01503 could epigenetically silence DUSP5/CDKN1A expression to mediate cell cycle progression and tumorigenesis, implicating it as a prospective target for GC therapeutics. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | EGR1?activated linc01503 could epigenetically silence DUSP5/CDKN1A expression to mediate cell cycle progression and tumorigenesis, implicating it as a prospective target for GC therapeutics. |
About TF
| TF name : | EGR1(AT225,G0S30,KROX-24,NGFI-A,TIS8,ZIF-268,ZNF225) |
| TF experiment: | RT-qPCR????????RNA?????RIP????????????ChIP?,?????????????FISH??? |
| TF experiment description: | EGR1?activated linc01503 could epigenetically silence DUSP5/CDKN1A expression to mediate cell cycle progression and tumorigenesis, implicating it as a prospective target for GC therapeutics. |
About Function
| Enhancer function : | EGR1?activated linc01503 could epigenetically silence DUSP5/CDKN1A expression to mediate cell cycle progression and tumorigenesis, implicating it as a prospective target for GC therapeutics. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
EGR1?activated linc01503 could epigenetically silence DUSP5/CDKN1A expression to mediate cell cycle progression and tumorigenesis, implicating it as a prospective target for GC therapeutics. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| EGR1 | AP-1 transcription factor network | pid | 71 |
| EGR1 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| EGR1 | Downstream signaling in nave CD8+ T cells | pid | 69 |
| EGR1 | ErbB1 downstream signaling | pid | 105 |
| EGR1 | Glucocorticoid receptor regulatory network | pid | 85 |
| EGR1 | Interferon alpha/beta signaling | reactome | 67 |
| EGR1 | Regulation of Androgen receptor activity | pid | 54 |
| EGR1 | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | pid | 80 |
| EGR1 | Signaling events mediated by PRL | pid | 23 |
| EGR1 | TCR | netpath | 261 |
| EGR1 | Trk receptor signaling mediated by PI3K and PLC-gamma | pid | 36 |
| EGR1 | Trk receptor signaling mediated by the MAPK pathway | pid | 34 |
| EGR1 | Prion diseases | kegg | 34 |
| EGR1 | Hs_Thyroid_Stimulating_Hormone_(TSH)_signaling_pathway_WP2032_89823 | wikipathways | 28 |
| EGR1 | Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 | wikipathways | 15 |
| EGR1 | Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 | wikipathways | 44 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene