About Enhancer

Enhancer ID: E_01_0871
Species: human
Position : chr14:104766534-104768534
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Mammary cancer
Pubmed ID:  33129761
Enhancer experiment: Cell transfection, IHC, Western blot, immunofluorescence, migration and invasion assays, semi quantitative analysis of immunostaining
Enhancer experiment description: The mechanistic analysis showed that SETD5 contributes BC progression by interacting with AKT1 pathway.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: The mechanistic analysis showed that SETD5 contributes BC progression by interacting with AKT1 pathway.

About TF

TF name : AKT1
TF experiment: ?????IHC, western blot, immunofluorescence, migration and invasion assays?Semi-quantitative analysis of immunostaining
TF experiment description: The mechanistic analysis showed that SETD5 contributes BC progression by interacting with AKT1 pathway.

About Function

Enhancer function : The mechanistic analysis showed that SETD5 contributes BC progression by interacting with AKT1 pathway.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 The mechanistic analysis showed that SETD5 contributes BC progression by interacting with AKT1 pathway.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
AKT1 a6b1 and a6b4 Integrin signaling pid 46
AKT1 Activation of BAD and translocation to mitochondria reactome 15
AKT1 AKT phosphorylates targets in the cytosol reactome 13
AKT1 AKT phosphorylates targets in the nucleus reactome 9
AKT1 AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) inoh 173
AKT1 AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) ) inoh 173
AKT1 AKT(PKB)-Bad signaling ( Insulin receptor signaling (D. melanogaster) ) inoh 11
AKT1 AKT(PKB)-Bad signaling ( Insulin receptor signaling (Mammal) ) inoh 11
AKT1 AKT(PKB)-GSK3beta signaling ( Insulin receptor signaling (D. melanogaster) ) inoh 6
AKT1 AKT(PKB)-GSK3beta signaling ( Insulin receptor signaling (Mammal) ) inoh 6
AKT1 AKT(PKB)-mTOR signaling ( Insulin receptor signaling (Mammal) ) inoh 15
AKT1 AKT(PKB)-TOR signaling ( Insulin receptor signaling (D. melanogaster) ) inoh 15
AKT1 AKT(PKB) activation signaling ( IGF1 signaling pathway ) inoh 7
AKT1 AKT(PKB) activation signaling ( Insulin receptor signaling (D. melanogaster) ) inoh 7
AKT1 AKT(PKB) activation signaling ( Insulin receptor signaling (Mammal) ) inoh 13
AKT1 AKT(PKB) activation signaling ( PDGF signaling pathway ) inoh 7
AKT1 Alpha6Beta4Integrin netpath 74
AKT1 AndrogenReceptor netpath 167
AKT1 Angiogenesis panther 141
AKT1 Angiopoietin receptor Tie2-mediated signaling pid 50
AKT1 Apoptosis signaling pathway panther 104
AKT1 Aurora A signaling pid 33
AKT1 BCR netpath 161
AKT1 BCR signaling pathway pid 70
AKT1 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA reactome 17
AKT1 Caspase Cascade in Apoptosis pid 57
AKT1 CD28 dependent PI3K/Akt signaling reactome 22
AKT1 CD28 signaling ( CD4 T cell receptor signaling (NF-kB cascade) ) inoh 14
AKT1 CD28 signaling ( CD4 T cell receptor signaling ) inoh 14
AKT1 CD40/CD40L signaling pid 36
AKT1 Ceramide signaling pathway pid 49
AKT1 Class I PI3K signaling events pid 46
AKT1 Class I PI3K signaling events mediated by Akt pid 35
AKT1 Constitutive Signaling by AKT1 E17K in Cancer reactome 25
AKT1 Coregulation of Androgen receptor activity pid 61
AKT1 CTLA4 inhibitory signaling reactome 22
AKT1 CXCR3-mediated signaling events pid 38
AKT1 CXCR4-mediated signaling events pid 87
AKT1 Cytokine gene transcription smpdb 11
AKT1 Deactivation of the beta-catenin transactivating complex reactome 42
AKT1 Downregulation of ERBB2:ERBB3 signaling reactome 13
AKT1 Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling ) inoh 236
AKT1 E-cadherin signaling in keratinocytes pid 21
AKT1 E-cadherin signaling in the nascent adherens junction pid 37
AKT1 EGF receptor signaling pathway panther 109
AKT1 EGFR1 netpath 475
AKT1 Endothelins pid 64
AKT1 eNOS activation reactome 12
AKT1 ErbB1 downstream signaling pid 105
AKT1 ErbB2/ErbB3 signaling events pid 41
AKT1 FAS (CD95) signaling pathway pid 36
AKT1 Fc-epsilon receptor I signaling in mast cells pid 64
AKT1 Fc Epsilon Receptor I Signaling in Mast Cells smpdb 36
AKT1 FGF signaling pathway panther 99
AKT1 FGF signaling pathway pid 55
AKT1 FOXA2 and FOXA3 transcription factor networks pid 45
AKT1 FoxO family signaling pid 50
AKT1 FSH netpath 44
AKT1 G beta:gamma signalling through PI3Kgamma reactome 48
AKT1 Glucocorticoid receptor regulatory network pid 85
AKT1 GPVI-mediated activation cascade reactome 55
AKT1 Hedgehog netpath 39
AKT1 Hedgehog signaling events mediated by Gli proteins pid 49
AKT1 HIF-1-alpha transcription factor network pid 67
AKT1 Huntington disease panther 113
AKT1 Hypoxia response via HIF activation panther 16
AKT1 IFN-gamma pathway pid 43
AKT1 IGF1 pathway pid 30
AKT1 IL-7 netpath 28
AKT1 IL1 netpath 69
AKT1 IL2 netpath 81
AKT1 IL2 signaling events mediated by PI3K pid 38
AKT1 IL3 netpath 84
AKT1 IL4-mediated signaling events pid 66
AKT1 IL4 netpath 75
AKT1 IL5 netpath 59
AKT1 IL6-mediated signaling events pid 48
AKT1 IL6 netpath 85
AKT1 IL8- and CXCR1-mediated signaling events pid 29
AKT1 IL8- and CXCR2-mediated signaling events pid 35
AKT1 IL9 netpath 24
AKT1 Inflammation mediated by chemokine and cytokine signaling pathway panther 189
AKT1 Insulin-mediated glucose transport pid 30
AKT1 Insulin Pathway pid 47
AKT1 Insulin receptor signaling (Mammal) ( Insulin receptor signaling (Mammal) ) inoh 58
AKT1 Insulin Signalling smpdb 17
AKT1 Integrin-linked kinase signaling pid 46
AKT1 Integrin alphaIIb beta3 signaling reactome 23
AKT1 Integrins in angiogenesis pid 66
AKT1 Interleukin signaling pathway panther 86
AKT1 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine smpdb 37
AKT1 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine smpdb 38
AKT1 KitReceptor netpath 104
AKT1 KSRP (KHSRP) binds and destabilizes mRNA reactome 17
AKT1 Leptin netpath 98
AKT1 Leucine Stimulation on Insulin Signaling smpdb 15
AKT1 LPA receptor mediated events pid 65
AKT1 mTOR signaling pathway pid 66
AKT1 mTOR signalling reactome 16
AKT1 Negative regulation of gene expression ( Insulin receptor signaling (D. melanogaster) ) inoh 7
AKT1 Negative regulation of gene expression ( Insulin receptor signaling (Mammal) ) inoh 7
AKT1 Negative regulation of the PI3K/AKT network reactome 8
AKT1 Nephrin/Neph1 signaling in the kidney podocyte pid 28
AKT1 Nongenotropic Androgen signaling pid 31
AKT1 Notch netpath 76
AKT1 p53 pathway by glucose deprivation panther 21
AKT1 p53 pathway panther 39
AKT1 p53 pathway pid 59
AKT1 p53 pathway feedback loops 2 panther 42
AKT1 p75(NTR)-mediated signaling pid 74
AKT1 PI3 kinase pathway panther 38
AKT1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling reactome 83
AKT1 PIP3 activates AKT signaling reactome 81
AKT1 Plasma membrane estrogen receptor signaling pid 42
AKT1 Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 178
AKT1 Prolactin netpath 105
AKT1 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 reactome 9
AKT1 RANKL netpath 84
AKT1 Ras Pathway panther 69
AKT1 Reelin signaling pathway pid 28
AKT1 Regulation of nuclear SMAD2/3 signaling pid 82
AKT1 Regulation of Telomerase pid 70
AKT1 Regulation of TP53 Activity through Acetylation reactome 23
AKT1 Regulation of TP53 Activity through Association with Co-factors reactome 14
AKT1 Regulation of TP53 Degradation reactome 35
AKT1 Retinoic acid receptors-mediated signaling pid 30
AKT1 S1P3 pathway pid 25
AKT1 Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) pid 80
AKT1 Signaling events mediated by PTP1B pid 53
AKT1 Signaling events mediated by Stem cell factor receptor (c-Kit) pid 53
AKT1 Signaling events mediated by the Hedgehog family pid 24
AKT1 Signaling events mediated by VEGFR1 and VEGFR2 pid 69
AKT1 T cell activation panther 60
AKT1 TCR netpath 261
AKT1 TCR signaling in nave CD4+ T cells pid 69
AKT1 TCR signaling in nave CD8+ T cells pid 56
AKT1 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation reactome 12
AKT1 TGF_beta_Receptor netpath 220
AKT1 Thromboxane A2 receptor signaling pid 56
AKT1 TNFalpha netpath 274
AKT1 TP53 Regulates Metabolic Genes reactome 85
AKT1 Translocation of GLUT4 to the plasma membrane reactome 62
AKT1 Trk receptor signaling mediated by PI3K and PLC-gamma pid 36
AKT1 TSH netpath 82
AKT1 TSLP netpath 24
AKT1 TWEAK netpath 35
AKT1 VEGF signaling pathway ( VEGF signaling pathway ) inoh 183
AKT1 VEGF signaling pathway panther 54
AKT1 VEGFR1 specific signals pid 29
AKT1 VEGFR2 mediated vascular permeability reactome 29
AKT1 VEGFR3 signaling in lymphatic endothelium pid 26
AKT1 Wnt netpath 118
AKT1 untitled panther 64
AKT1 MAPK signaling pathway kegg 264
AKT1 ErbB signaling pathway kegg 83
AKT1 Chemokine signaling pathway kegg 187
AKT1 mTOR signaling pathway kegg 50
AKT1 Apoptosis kegg 88
AKT1 VEGF signaling pathway kegg 70
AKT1 Focal adhesion kegg 197
AKT1 Tight junction kegg 131
AKT1 Toll-like receptor signaling pathway kegg 100
AKT1 Jak-STAT signaling pathway kegg 149
AKT1 T cell receptor signaling pathway kegg 105
AKT1 B cell receptor signaling pathway kegg 70
AKT1 Fc epsilon RI signaling pathway kegg 75
AKT1 Fc gamma R-mediated phagocytosis kegg 83
AKT1 Neurotrophin signaling pathway kegg 126
AKT1 Insulin signaling pathway kegg 134
AKT1 Progesterone-mediated oocyte maturation kegg 84
AKT1 Adipocytokine signaling pathway kegg 65
AKT1 Carbohydrate digestion and absorption kegg 40
AKT1 Chagas disease kegg 103
AKT1 Toxoplasmosis kegg 131
AKT1 Hepatitis C kegg 134
AKT1 Pathways in cancer kegg 321
AKT1 Colorectal cancer kegg 63
AKT1 Renal cell carcinoma kegg 65
AKT1 Pancreatic cancer kegg 70
AKT1 Endometrial cancer kegg 52
AKT1 Glioma kegg 65
AKT1 Prostate cancer kegg 85
AKT1 Melanoma kegg 69
AKT1 Chronic myeloid leukemia kegg 69
AKT1 Acute myeloid leukemia kegg 53
AKT1 Small cell lung cancer kegg 83
AKT1 Non-small cell lung cancer kegg 54
AKT1 Hs_BDNF-TrkB_Signaling_WP3676_89741 wikipathways 14
AKT1 Hs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278 wikipathways 51
AKT1 Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 wikipathways 41
AKT1 Hs_Association_Between_Physico-Chemical_Features_and_Toxicity_Associated_Pathways_WP3680_90113 wikipathways 31
AKT1 Hs_Factors_and_pathways_affecting_insulin-like_growth_factor_(IGF1)-Akt_signaling_WP3850_88165 wikipathways 19
AKT1 Hs_Thyroid_Stimulating_Hormone_(TSH)_signaling_pathway_WP2032_89823 wikipathways 28
AKT1 Hs_Leptin_signaling_pathway_WP2034_89856 wikipathways 37
AKT1 Hs_PI3K-AKT-mTOR_signaling_pathway_and_therapeutic_opportunities_WP3844_89952 wikipathways 5
AKT1 Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 wikipathways 36
AKT1 Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 wikipathways 17
AKT1 Hs_Apoptosis_WP254_88977 wikipathways 31
AKT1 Hs_Primary_Focal_Segmental_Glomerulosclerosis_FSGS_WP2572_90019 wikipathways 7
AKT1 Hs_Target_Of_Rapamycin_(TOR)_Signaling_WP1471_90258 wikipathways 5
AKT1 Hs_Wnt_Signaling_Pathway_Netpath_WP363_78571 wikipathways 28
AKT1 Hs_Angiogenesis_WP1539_88983 wikipathways 17
AKT1 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
AKT1 Hs_T-Cell_antigen_Receptor_(TCR)_pathway_during_Staphylococcus_aureus_infection_WP3863_90702 wikipathways 35
AKT1 Hs_Copper_homeostasis_WP3286_89205 wikipathways 15
AKT1 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
AKT1 Hs_Integrated_Cancer_Pathway_WP1971_82939 wikipathways 33
AKT1 Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 wikipathways 27
AKT1 Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 wikipathways 44
AKT1 Hs_TNF_related_weak_inducer_of_apoptosis_(TWEAK)_Signaling_Pathway_WP2036_89910 wikipathways 27
AKT1 Hs_Rac1-Pak1-p38-MMP-2_pathway_WP3303_87628 wikipathways 32
AKT1 Hs_Complement_Activation_WP545_89636 wikipathways 6
AKT1 Hs_Integrin-mediated_Cell_Adhesion_WP185_88160 wikipathways 38
AKT1 Hs_Sterol_Regulatory_Element-Binding_Proteins_(SREBP)_signalling_WP1982_90425 wikipathways 15
AKT1 Hs_IL17_signaling_pathway_WP2112_89838 wikipathways 20
AKT1 Hs_Regulation_of_Microtubule_Cytoskeleton_WP2038_90889 wikipathways 38
AKT1 Hs_Estrogen_signaling_pathway_WP712_78491 wikipathways 13
AKT1 Hs_Kit_receptor_signaling_pathway_WP304_78799 wikipathways 46
AKT1 Hs_IL-5_Signaling_Pathway_WP127_78498 wikipathways 35
AKT1 Hs_IL-2_Signaling_Pathway_WP49_91243 wikipathways 33
AKT1 Hs_TGF-beta_Signaling_Pathway_WP366_90028 wikipathways 67
AKT1 Hs_IL-6_signaling_pathway_WP364_89832 wikipathways 26
AKT1 Hs_Prolactin_Signaling_Pathway_WP2037_90015 wikipathways 52
AKT1 Hs_AGE-RAGE_pathway_WP2324_89798 wikipathways 27
AKT1 Hs_Androgen_receptor_signaling_pathway_WP138_79958 wikipathways 27
AKT1 Hs_IL-4_Signaling_Pathway_WP395_89828 wikipathways 41
AKT1 Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 wikipathways 80
AKT1 Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 wikipathways 107
AKT1 Hs_T-Cell_antigen_Receptor_(TCR)_Signaling_Pathway_WP69_89937 wikipathways 60
AKT1 Hs_Alpha_6_Beta_4_signaling_pathway_WP244_85199 wikipathways 19
AKT1 Hs_IL-1_signaling_pathway_WP195_89932 wikipathways 34
AKT1 Hs_IL-3_Signaling_Pathway_WP286_78583 wikipathways 35
AKT1 Hs_IL-7_Signaling_Pathway_WP205_89854 wikipathways 16
AKT1 Hs_Notch_Signaling_Pathway_WP61_78592 wikipathways 16
AKT1 Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 wikipathways 26
AKT1 Hs_Follicle_Stimulating_Hormone_(FSH)_signaling_pathway_WP2035_86080 wikipathways 20
AKT1 Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 wikipathways 71

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs