About Enhancer

Enhancer ID: E_01_0887
Species: human
Position : chr9:136491743-136493743
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Lymphocytic leukemia
Pubmed ID:  31467127
Enhancer experiment: PCR, gel electrophoresis
Enhancer experiment description: Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription.

About TF

TF name : NOTCH1(AOS5,AOVD1,TAN1,hN1)
TF experiment: PCR,????
TF experiment description: Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription.

About Function

Enhancer function : Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
NOTCH1 A third proteolytic cleavage releases NICD reactome 9
NOTCH1 Activated NOTCH1 Transmits Signal to the Nucleus reactome 30
NOTCH1 Alzheimer disease-presenilin pathway panther 98
NOTCH1 Angiogenesis panther 141
NOTCH1 C. elegans Notch signaling pathway ( Notch signaling pathway Diagram ) inoh 8
NOTCH1 Canonical Notch signaling pathway ( Notch signaling pathway Diagram ) inoh 19
NOTCH1 Constitutive Signaling by NOTCH1 HD Domain Mutants reactome 15
NOTCH1 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants reactome 57
NOTCH1 Constitutive Signaling by NOTCH1 PEST Domain Mutants reactome 57
NOTCH1 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant reactome 7
NOTCH1 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling reactome 5
NOTCH1 Mammalian Notch signaling pathway ( Notch signaling pathway Diagram ) inoh 15
NOTCH1 NICD traffics to nucleus reactome 13
NOTCH1 Notch-HLH transcription pathway reactome 13
NOTCH1 Notch-mediated HES/HEY network pid 48
NOTCH1 Notch netpath 76
NOTCH1 Notch degradation signaling ( Notch signaling pathway Diagram ) inoh 5
NOTCH1 Notch degradation signaling (Mammal) ( Notch signaling pathway Diagram ) inoh 5
NOTCH1 Notch secretory pathway ( Notch signaling pathway Diagram ) inoh 5
NOTCH1 Notch secretory pathway (C. elegans) ( Notch signaling pathway Diagram ) inoh 5
NOTCH1 Notch signaling pathway panther 27
NOTCH1 Notch signaling pathway pid 58
NOTCH1 NOTCH1 Intracellular Domain Regulates Transcription reactome 47
NOTCH1 Pre-NOTCH Processing in Golgi reactome 18
NOTCH1 Pre-NOTCH Processing in the Endoplasmic Reticulum reactome 6
NOTCH1 Pre-NOTCH Transcription and Translation reactome 29
NOTCH1 Presenilin action in Notch and Wnt signaling pid 46
NOTCH1 Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor reactome 14
NOTCH1 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells reactome 7
NOTCH1 Validated transcriptional targets of deltaNp63 isoforms pid 47
NOTCH1 Dorso-ventral axis formation kegg 25
NOTCH1 Notch signaling pathway kegg 44
NOTCH1 Hs_Gastric_Cancer_Network_1_WP2361_86831 wikipathways 26
NOTCH1 Hs_PI3K-AKT-mTOR_signaling_pathway_and_therapeutic_opportunities_WP3844_89952 wikipathways 5
NOTCH1 Hs_Primary_Focal_Segmental_Glomerulosclerosis_FSGS_WP2572_90019 wikipathways 7
NOTCH1 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
NOTCH1 Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 wikipathways 27
NOTCH1 Hs_Heart_Development_WP1591_90186 wikipathways 28
NOTCH1 Hs_Gene_regulatory_network_modelling_somitogenesis_WP2854_87527 wikipathways 12
NOTCH1 Hs_Amplification_and_Expansion_of_Oncogenic_Pathways_as_Metastatic_Traits_WP3678_90110 wikipathways 5

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs