About Enhancer

Enhancer ID: E_01_0896
Species: human
Position : chr7:148804518-148806518
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Nothing
Pubmed ID:  31423206
Enhancer experiment: --
Enhancer experiment description: The purpose of the present study was to investigate the clinical significance of enhancer of zeste homolog 2 (EZH2) and histone deacetylase 1 and 2 (HDAC1/2) expression in PTCL.

About Target gene

Target gene : HDAC2
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: The purpose of the present study was to investigate the clinical significance of enhancer of zeste homolog 2 (EZH2) and histone deacetylase 1 and 2 (HDAC1/2) expression in PTCL.;The purpose of the present study was to investigate the clinical significance of enhancer of zeste homolog 2 (EZH2) and histone deacetylase 1 and 2 (HDAC1/2) expression in PTCL.;The purpose of the present study was to investigate the clinical significance of enhancer of zeste homolog 2 (EZH2) and histone deacetylase 1 and 2 (HDAC1/2) expression in PTCL.

About TF

TF name : EZH2(ENX-1,ENX1b,KMT6,KMT6A,WVS,WVS2,EZH2)HDAC1
TF experiment: --
TF experiment description: The purpose of the present study was to investigate the clinical significance of enhancer of zeste homolog 2 (EZH2) and histone deacetylase 1 and 2 (HDAC1/2) expression in PTCL.;The purpose of the present study was to investigate the clinical significance of enhancer of zeste homolog 2 (EZH2) and histone deacetylase 1 and 2 (HDAC1/2) expression in PTCL.;The purpose of the present study was to investigate the clinical significance of enhancer of zeste homolog 2 (EZH2) and histone deacetylase 1 and 2 (HDAC1/2) expression in PTCL.

About Function

Enhancer function : The purpose of the present study was to investigate the clinical significance of enhancer of zeste homolog 2 (EZH2) and histone deacetylase 1 and 2 (HDAC1/2) expression in PTCL.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 The purpose of the present study was to investigate the clinical significance of enhancer of zeste homolog 2 (EZH2) and histone deacetylase 1 and 2 (HDAC1/2) expression in PTCL.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
EZH2 Activation of anterior HOX genes in hindbrain development during early embryogenesis reactome 120
EZH2 Oxidative Stress Induced Senescence reactome 120
EZH2 PKMTs methylate histone lysines reactome 64
EZH2 PRC2 methylates histones and DNA reactome 71
EZH2 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
EZH2 Hs_Interactome_of_polycomb_repressive_complex_2_(PRC2)_WP2916_88672 wikipathways 15
HDAC1 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) reactome 74
HDAC1 AndrogenReceptor netpath 167
HDAC1 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants reactome 57
HDAC1 Constitutive Signaling by NOTCH1 PEST Domain Mutants reactome 57
HDAC1 Deactivation of the beta-catenin transactivating complex reactome 42
HDAC1 Downregulation of SMAD2/3:SMAD4 transcriptional activity reactome 23
HDAC1 E2F transcription factor network pid 77
HDAC1 EGFR1 netpath 475
HDAC1 Factors involved in megakaryocyte development and platelet production reactome 111
HDAC1 Formation of the beta-catenin:TCF transactivating complex reactome 88
HDAC1 G0 and Early G1 reactome 25
HDAC1 Glucocorticoid receptor regulatory network pid 85
HDAC1 HDACs deacetylate histones reactome 94
HDAC1 Hedgehog signaling events mediated by Gli proteins pid 49
HDAC1 IL3-mediated signaling events pid 27
HDAC1 IL6 netpath 85
HDAC1 Negative regulation of (transcription by R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) inoh 21
HDAC1 NoRC negatively regulates rRNA expression reactome 104
HDAC1 Notch-mediated HES/HEY network pid 48
HDAC1 Notch netpath 76
HDAC1 Notch signaling pathway pid 58
HDAC1 NOTCH1 Intracellular Domain Regulates Transcription reactome 47
HDAC1 p53 pathway panther 39
HDAC1 p75NTR negatively regulates cell cycle via SC1 reactome 6
HDAC1 Presenilin action in Notch and Wnt signaling pid 46
HDAC1 Regulation of Androgen receptor activity pid 54
HDAC1 Regulation of nuclear beta catenin signaling and target gene transcription pid 80
HDAC1 Regulation of nuclear SMAD2/3 signaling pid 82
HDAC1 Regulation of retinoblastoma protein pid 67
HDAC1 Regulation of Telomerase pid 70
HDAC1 Regulation of TP53 Activity through Acetylation reactome 23
HDAC1 Repression of WNT target genes reactome 14
HDAC1 Retinoic acid receptors-mediated signaling pid 30
HDAC1 RNA Polymerase I Transcription Initiation reactome 47
HDAC1 Signaling events mediated by HDAC Class I pid 89
HDAC1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription reactome 32
HDAC1 Sumoylation by RanBP2 regulates transcriptional repression pid 15
HDAC1 TGF_beta_Receptor netpath 220
HDAC1 TNFalpha netpath 274
HDAC1 TWEAK netpath 35
HDAC1 Validated nuclear estrogen receptor alpha network pid 65
HDAC1 Validated targets of C-MYC transcriptional repression pid 63
HDAC1 Wnt signaling pathway panther 250
HDAC1 Cell cycle kegg 124
HDAC1 Notch signaling pathway kegg 44
HDAC1 Huntington's disease kegg 182
HDAC1 Pathways in cancer kegg 321
HDAC1 Chronic myeloid leukemia kegg 69
HDAC1 Hs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278 wikipathways 51
HDAC1 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
HDAC1 Hs_Energy_Metabolism_WP1541_91584 wikipathways 13
HDAC1 Hs_IL-6_signaling_pathway_WP364_89832 wikipathways 26
HDAC1 Hs_Androgen_receptor_signaling_pathway_WP138_79958 wikipathways 27
HDAC1 Hs_Notch_Signaling_Pathway_WP61_78592 wikipathways 16

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs