About Enhancer

Enhancer ID: E_01_0899
Species: human
Position : chr7:148803950-148805950
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Cancer (cancer)
Pubmed ID:  31419226
Enhancer experiment: PCR, gel electrophoresis
Enhancer experiment description: DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations.;DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations.;DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations.;DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations.

About TF

TF name : EZH2(ENX-1,ENX1b,KMT6,KMT6A,WVS,WVS2,EZH2)MYC(MRTLC,bHLHe39,c-Myc,MYC)BCL2BCL6
TF experiment: PCR,????
TF experiment description: DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations.;DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations.;DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations.;DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations.

About Function

Enhancer function : DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
EZH2 Activation of anterior HOX genes in hindbrain development during early embryogenesis reactome 120
EZH2 Oxidative Stress Induced Senescence reactome 120
EZH2 PKMTs methylate histone lysines reactome 64
EZH2 PRC2 methylates histones and DNA reactome 71
EZH2 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62
EZH2 Hs_Interactome_of_polycomb_repressive_complex_2_(PRC2)_WP2916_88672 wikipathways 15
MYC AP-1 transcription factor network pid 71
MYC Binding of TCF/LEF:CTNNB1 to target gene promoters reactome 7
MYC C-MYB transcription factor network pid 87
MYC C-MYC pathway pid 25
MYC CD40/CD40L signaling pid 36
MYC Ceramide signaling pathway pid 49
MYC Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants reactome 57
MYC Constitutive Signaling by NOTCH1 PEST Domain Mutants reactome 57
MYC Cyclin A:Cdk2-associated events at S phase entry reactome 15
MYC Cyclin E associated events during G1/S transition reactome 14
MYC E2F transcription factor network pid 77
MYC EGFR1 netpath 475
MYC Formation of the beta-catenin:TCF transactivating complex reactome 88
MYC FOXM1 transcription factor network pid 43
MYC IL2-mediated signaling events pid 54
MYC IL2 signaling events mediated by PI3K pid 38
MYC IL2 signaling events mediated by STAT5 pid 30
MYC IL6-mediated signaling events pid 48
MYC Interleukin signaling pathway panther 86
MYC LKB1 signaling events pid 43
MYC MAPK6/MAPK4 signaling reactome 90
MYC Notch signaling pathway pid 58
MYC NOTCH1 Intracellular Domain Regulates Transcription reactome 47
MYC Oxidative stress response panther 23
MYC p53 pathway feedback loops 2 panther 42
MYC p73 transcription factor network pid 80
MYC PDGF signaling pathway panther 113
MYC PDGFR-beta signaling pathway pid 125
MYC Presenilin action in Notch and Wnt signaling pid 46
MYC Prolactin netpath 105
MYC Regulation of nuclear beta catenin signaling and target gene transcription pid 80
MYC Regulation of nuclear SMAD2/3 signaling pid 82
MYC Regulation of Telomerase pid 70
MYC SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription reactome 32
MYC TGF_beta_Receptor netpath 220
MYC Validated nuclear estrogen receptor alpha network pid 65
MYC Validated targets of C-MYC transcriptional activation pid 80
MYC Validated targets of C-MYC transcriptional repression pid 63
MYC MAPK signaling pathway kegg 264
MYC ErbB signaling pathway kegg 83
MYC Cell cycle kegg 124
MYC Wnt signaling pathway kegg 135
MYC TGF-beta signaling pathway kegg 82
MYC Jak-STAT signaling pathway kegg 149
MYC Pathways in cancer kegg 321
MYC Colorectal cancer kegg 63
MYC Endometrial cancer kegg 52
MYC Thyroid cancer kegg 25
MYC Bladder cancer kegg 38
MYC Chronic myeloid leukemia kegg 69
MYC Acute myeloid leukemia kegg 53
MYC Small cell lung cancer kegg 83
MYC Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974 wikipathways 36
MYC Hs_TP53_Network_WP1742_71700 wikipathways 10
MYC Hs_Imatinib_and_Chronic_Myeloid_Leukemia_WP3640_89384 wikipathways 11
MYC Hs_miRNAs_involved_in_DNA_damage_response_WP1545_84697 wikipathways 30
MYC Hs_Association_Between_Physico-Chemical_Features_and_Toxicity_Associated_Pathways_WP3680_90113 wikipathways 31
MYC Hs_Gastric_Cancer_Network_2_WP2363_87523 wikipathways 28
MYC Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 wikipathways 36
MYC Hs_Apoptosis_WP254_88977 wikipathways 31
MYC Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
MYC Hs_Neural_Crest_Differentiation_WP2064_79263 wikipathways 40
MYC Hs_IL-5_Signaling_Pathway_WP127_78498 wikipathways 35
MYC Hs_Prolactin_Signaling_Pathway_WP2037_90015 wikipathways 52
MYC Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 wikipathways 107
MYC Hs_IL-7_Signaling_Pathway_WP205_89854 wikipathways 16
BCL2 Activation of BAD and translocation to mitochondria reactome 15
BCL2 Apoptosis signaling pathway panther 104
BCL2 ATF-2 transcription factor network pid 59
BCL2 BCR netpath 161
BCL2 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members reactome 8
BCL2 C-MYB transcription factor network pid 87
BCL2 Caspase Cascade in Apoptosis pid 57
BCL2 Ceramide signaling pathway pid 49
BCL2 Direct p53 effectors pid 141
BCL2 EGFR1 netpath 475
BCL2 EPO signaling pathway pid 33
BCL2 HIV-1 Nef: Negative effector of Fas and TNF-alpha pid 33
BCL2 IL2-mediated signaling events pid 54
BCL2 IL2 netpath 81
BCL2 IL2 signaling events mediated by PI3K pid 38
BCL2 IL2 signaling events mediated by STAT5 pid 30
BCL2 IL3 netpath 84
BCL2 Oxidative stress response panther 23
BCL2 Role of Calcineurin-dependent NFAT signaling in lymphocytes pid 54
BCL2 RXR and RAR heterodimerization with other nuclear receptor pid 26
BCL2 Signaling events mediated by Stem cell factor receptor (c-Kit) pid 53
BCL2 Validated targets of C-MYC transcriptional repression pid 63
BCL2 Protein processing in endoplasmic reticulum kegg 166
BCL2 Apoptosis kegg 88
BCL2 Focal adhesion kegg 197
BCL2 Neurotrophin signaling pathway kegg 126
BCL2 Amyotrophic lateral sclerosis (ALS) kegg 53
BCL2 Toxoplasmosis kegg 131
BCL2 Pathways in cancer kegg 321
BCL2 Colorectal cancer kegg 63
BCL2 Prostate cancer kegg 85
BCL2 Small cell lung cancer kegg 83
BCL2 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
BCL2 Hs_Apoptosis_Modulation_and_Signaling_WP1772_91293 wikipathways 71
BCL2 Hs_Integrated_Cancer_Pathway_WP1971_82939 wikipathways 33
BCL6 BCR netpath 161
BCL6 BCR signaling pathway pid 70
BCL6 Direct p53 effectors pid 141
BCL6 FoxO family signaling pid 50
BCL6 IL4-mediated signaling events pid 66
BCL6 Signaling events mediated by HDAC Class II pid 58
BCL6 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain reactome 14
BCL6 Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 wikipathways 26

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs