About Enhancer

Enhancer ID: E_01_0904
Species: human
Position : chr9:127782971-127784971
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Cancer (cancer)
Pubmed ID:  31399571
Enhancer experiment: PCR, RT qPCR, RNA SEQ, gel electrophoresis
Enhancer experiment description: Gene activation generally requires the activity of the P-TEFb kinase CDK9, which decreases the duration of Pol II pausing and thereby enables an increase in the productive initiation frequency.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: Gene activation generally requires the activity of the P-TEFb kinase CDK9, which decreases the duration of Pol II pausing and thereby enables an increase in the productive initiation frequency.

About TF

TF name : CDK9(C-2k,CDC2L4,CTK1,PITALRE,TAK)
TF experiment: PCR,RT-qPCR,RNA-seq,????
TF experiment description: Gene activation generally requires the activity of the P-TEFb kinase CDK9, which decreases the duration of Pol II pausing and thereby enables an increase in the productive initiation frequency.

About Function

Enhancer function : Gene activation generally requires the activity of the P-TEFb kinase CDK9, which decreases the duration of Pol II pausing and thereby enables an increase in the productive initiation frequency.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:
Gene activation generally requires the activity of the P-TEFb kinase CDK9, which decreases the duration of Pol II pausing and thereby enables an increase in the productive initiation frequency.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
CDK9 AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) inoh 173
CDK9 AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) ) inoh 173
CDK9 AndrogenReceptor netpath 167
CDK9 Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling ) inoh 236
CDK9 Elongation arrest and recovery reactome 32
CDK9 Formation of HIV-1 elongation complex containing HIV-1 Tat reactome 42
CDK9 Formation of HIV elongation complex in the absence of HIV Tat reactome 44
CDK9 Formation of RNA Pol II elongation complex reactome 44
CDK9 HIV elongation arrest and recovery reactome 32
CDK9 IL6 netpath 85
CDK9 Pausing and recovery of HIV elongation reactome 32
CDK9 Pausing and recovery of Tat-mediated HIV elongation reactome 30
CDK9 Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 178
CDK9 RNA Polymerase II Pre-transcription Events reactome 64
CDK9 RNA polymerase II transcribes snRNA genes reactome 70
CDK9 RNA Polymerase II Transcription Elongation reactome 42
CDK9 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription reactome 32
CDK9 Tat-mediated elongation of the HIV-1 transcript reactome 40
CDK9 Tat-mediated HIV elongation arrest and recovery reactome 30
CDK9 TNFalpha netpath 274
CDK9 TP53 Regulates Transcription of DNA Repair Genes reactome 61
CDK9 VEGF signaling pathway ( VEGF signaling pathway ) inoh 183
CDK9 Hs_IL-9_Signaling_Pathway_WP22_79264 wikipathways 11

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs