About Enhancer
| Enhancer ID: | E_01_0950 |
| Species: | human |
| Position : | chr11:102108307-102110307   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Ovarian cancer |
| Pubmed ID: | 32654106 |
| Enhancer experiment: | RT-PCR,Western blot,Immunoprecipitation |
| Enhancer experiment description: | Mechanically, immunoprecipitation (IP) was used to show that LATS2 interacted with YAP1 and subsequently limited nuclear translocation of YAP1; chromatin immunoprecipitation (ChIP) was used to confrm that YAP1 could bind to enhancer region of PD-L1 to enhance transcription activity of PD-L1. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Mechanically, immunoprecipitation (IP) was used to show that LATS2 interacted with YAP1 and subsequently limited nuclear translocation of YAP1; chromatin immunoprecipitation (ChIP) was used to confrm that YAP1 could bind to enhancer region of PD-L1 to enhance transcription activity of PD-L1. |
About TF
| TF name : | YAP1(AI325207,Yap,Yap65,Yki,Yorkie) |
| TF experiment: | RT-PCR,Western blot,Immunoprecipitation |
| TF experiment description: | Mechanically, immunoprecipitation (IP) was used to show that LATS2 interacted with YAP1 and subsequently limited nuclear translocation of YAP1; chromatin immunoprecipitation (ChIP) was used to confrm that YAP1 could bind to enhancer region of PD-L1 to enhance transcription activity of PD-L1. |
About Function
| Enhancer function : | Mechanically, immunoprecipitation (IP) was used to show that LATS2 interacted with YAP1 and subsequently limited nuclear translocation of YAP1; chromatin immunoprecipitation (ChIP) was used to confrm that YAP1 could bind to enhancer region of PD-L1 to enhance transcription activity of PD-L1. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Mechanically, immunoprecipitation (IP) was used to show that LATS2 interacted with YAP1 and subsequently limited nuclear translocation of YAP1; chromatin immunoprecipitation (ChIP) was used to confrm that YAP1 could bind to enhancer region of PD-L1 to enhance transcription activity of PD-L1. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| YAP1 | ErbB4 signaling events | pid | 35 |
| YAP1 | Nuclear signaling by ERBB4 | reactome | 25 |
| YAP1 | p73 transcription factor network | pid | 80 |
| YAP1 | PPARA activates gene expression | reactome | 113 |
| YAP1 | Signaling by Hippo | reactome | 20 |
| YAP1 | TGF-beta receptor signaling | pid | 53 |
| YAP1 | TGF_beta_Receptor | netpath | 220 |
| YAP1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| YAP1 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| YAP1 | Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 | wikipathways | 50 |
| YAP1 | Hs_miR-509-3p_alteration_of_YAP1-ECM_axis_WP3967_91491 | wikipathways | 14 |
| YAP1 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
| YAP1 | Hs_TGF-beta_Signaling_Pathway_WP366_90028 | wikipathways | 67 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene