About Enhancer
| Enhancer ID: |
E_01_0951 |
| Species: |
human |
| Position :
|
chr7:27097694-27099694
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
Bilateral microtia |
| Pubmed ID: |
32649979
|
| Enhancer experiment: |
PCR |
| Enhancer experiment description: |
Using dual luciferase reporter assays,we showed that both HOXA2 mutations have impaired activation of the long-range enhancer of HMX1. |
About Target gene
| Target gene : |
HMX1 |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
Using dual luciferase reporter assays,we showed that both HOXA2 mutations have impaired activation of the long-range enhancer of HMX1.;Using dual luciferase reporter assays,we showed that both HOXA2 mutations have impaired activation of the long-range enhancer of HMX1. |
About TF
| TF name : |
HOXA2 |
| TF experiment: |
PCR |
| TF experiment description: |
Using dual luciferase reporter assays,we showed that both HOXA2 mutations have impaired activation of the long-range enhancer of HMX1.;Using dual luciferase reporter assays,we showed that both HOXA2 mutations have impaired activation of the long-range enhancer of HMX1. |
About Function
| Enhancer function : |
Using dual luciferase reporter assays,we showed that both HOXA2 mutations have impaired activation of the long-range enhancer of HMX1. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
Using dual luciferase reporter assays,we showed that both HOXA2 mutations have impaired activation of the long-range enhancer of HMX1. |
About SNP
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs