About Enhancer
| Enhancer ID: | E_01_0964 |
| Species: | human |
| Position : | chr1:91677376-91679376   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 33062456 |
| Enhancer experiment: | RT-qPCR |
| Enhancer experiment description: | Further study showed that SB431542, an inhibitor of the TGF-?/BMP signaling,significantly suppressed the mRNA expression of TGFBR3, BMP4, BMP7, BMPR1B,SMAD3, SMAD4, and the pro-proliferative effect of HA on hAECs. |
About Target gene
| Target gene : | TGFBR3(BGCAN,betaglycan) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Further study showed that SB431542, an inhibitor of the TGF-?/BMP signaling,significantly suppressed the mRNA expression of TGFBR3, BMP4, BMP7, BMPR1B,SMAD3, SMAD4, and the pro-proliferative effect of HA on hAECs.;Further study showed that SB431542, an inhibitor of the TGF-?/BMP signaling,significantly suppressed the mRNA expression of TGFBR3, BMP4, BMP7, BMPR1B,SMAD3, SMAD4, and the pro-proliferative effect of HA on hAECs. |
About TF
| TF name : | SMAD3 |
| TF experiment: | RT-qPCR |
| TF experiment description: | Further study showed that SB431542, an inhibitor of the TGF-?/BMP signaling,significantly suppressed the mRNA expression of TGFBR3, BMP4, BMP7, BMPR1B,SMAD3, SMAD4, and the pro-proliferative effect of HA on hAECs.;Further study showed that SB431542, an inhibitor of the TGF-?/BMP signaling,significantly suppressed the mRNA expression of TGFBR3, BMP4, BMP7, BMPR1B,SMAD3, SMAD4, and the pro-proliferative effect of HA on hAECs. |
About Function
| Enhancer function : | Further study showed that SB431542, an inhibitor of the TGF-?/BMP signaling,significantly suppressed the mRNA expression of TGFBR3, BMP4, BMP7, BMPR1B,SMAD3, SMAD4, and the pro-proliferative effect of HA on hAECs. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Further study showed that SB431542, an inhibitor of the TGF-?/BMP signaling,significantly suppressed the mRNA expression of TGFBR3, BMP4, BMP7, BMPR1B,SMAD3, SMAD4, and the pro-proliferative effect of HA on hAECs. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene