About Enhancer

Enhancer ID: E_01_0965
Species: human
Position : chr13:48301408-48303408
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: --
Pubmed ID:  33061937
Enhancer experiment: PCR
Enhancer experiment description: The present study analyses the regulatory activity of a Human Alu sequence from the AluSx family located in the second intron of the long intergenic non-coding RNA Linc00441, found in divergent orientation to the RB1 gene.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: The present study analyses the regulatory activity of a Human Alu sequence from the AluSx family located in the second intron of the long intergenic non-coding RNA Linc00441, found in divergent orientation to the RB1 gene.

About TF

TF name : RB1
TF experiment: PCR
TF experiment description: The present study analyses the regulatory activity of a Human Alu sequence from the AluSx family located in the second intron of the long intergenic non-coding RNA Linc00441, found in divergent orientation to the RB1 gene.

About Function

Enhancer function : The present study analyses the regulatory activity of a Human Alu sequence from the AluSx family located in the second intron of the long intergenic non-coding RNA Linc00441, found in divergent orientation to the RB1 gene.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 The present study analyses the regulatory activity of a Human Alu sequence from the AluSx family located in the second intron of the long intergenic non-coding RNA Linc00441, found in divergent orientation to the RB1 gene.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
RB1 AndrogenReceptor netpath 167
RB1 ATF-2 transcription factor network pid 59
RB1 BCR netpath 161
RB1 Ceramide signaling pathway pid 49
RB1 Condensation of Prophase Chromosomes reactome 72
RB1 Cyclin A:Cdk2-associated events at S phase entry reactome 15
RB1 Cyclin D associated events in G1 reactome 38
RB1 Cyclin E associated events during G1/S transition reactome 14
RB1 Direct p53 effectors pid 141
RB1 E2F transcription factor network pid 77
RB1 Formation of Senescence-Associated Heterochromatin Foci (SAHF) reactome 17
RB1 FOXM1 transcription factor network pid 43
RB1 ID netpath 38
RB1 IL1 netpath 69
RB1 IL3 netpath 84
RB1 IL6 netpath 85
RB1 Inhibition of replication initiation of damaged DNA by RB1/E2F1 reactome 12
RB1 Notch-mediated HES/HEY network pid 48
RB1 Orc1 removal from chromatin reactome 70
RB1 p53 pathway feedback loops 2 panther 42
RB1 p73 transcription factor network pid 80
RB1 Prolactin netpath 105
RB1 Regulation of retinoblastoma protein pid 67
RB1 TGF_beta_Receptor netpath 220
RB1 TNFalpha netpath 274
RB1 TSH netpath 82
RB1 Cell cycle kegg 124
RB1 Pathways in cancer kegg 321
RB1 Pancreatic cancer kegg 70
RB1 Glioma kegg 65
RB1 Prostate cancer kegg 85
RB1 Melanoma kegg 69
RB1 Bladder cancer kegg 38
RB1 Chronic myeloid leukemia kegg 69
RB1 Small cell lung cancer kegg 83
RB1 Non-small cell lung cancer kegg 54
RB1 Hs_Thyroid_Stimulating_Hormone_(TSH)_signaling_pathway_WP2032_89823 wikipathways 28
RB1 Hs_MAPK_Signaling_Pathway_WP382_79951 wikipathways 58
RB1 Hs_Leptin_and_adiponectin_WP3934_90768 wikipathways 5
RB1 Hs_Senescence_and_Autophagy_in_Cancer_WP615_81193 wikipathways 62
RB1 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
RB1 Hs_Integrated_Cancer_Pathway_WP1971_82939 wikipathways 33
RB1 Hs_Bladder_Cancer_WP2828_89143 wikipathways 17
RB1 Hs_Signaling_Pathways_in_Glioblastoma_WP2261_89520 wikipathways 16
RB1 Hs_Aryl_Hydrocarbon_Receptor_WP2586_91687 wikipathways 16
RB1 Hs_Retinoblastoma_(RB)_in_Cancer_WP2446_87639 wikipathways 5

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs