About Enhancer

Enhancer ID: E_01_0997
Species: human
Position : chr5:88714258-88716258
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Acute myeloid leukemia
Pubmed ID:  32017069
Enhancer experiment: RT-QPCR
Enhancer experiment description: The myocyte enhancer factor 2C gene (MEF2C), located at chromosome 5q14.3, encodes a transcription factor from the MCM1-agamous-deficiens_x0002_serum response factor family (Potthoff & Olson, 2007)

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: The myocyte enhancer factor 2C gene (MEF2C), located at chromosome 5q14.3, encodes a transcription factor from the MCM1-agamous-deficiens_x0002_serum response factor family (Potthoff & Olson, 2007)

About TF

TF name : MEF2C(5430401D19Rik,9930028G15Rik,AV011172,Mef2)
TF experiment: RT-QPCR
TF experiment description: The myocyte enhancer factor 2C gene (MEF2C), located at chromosome 5q14.3, encodes a transcription factor from the MCM1-agamous-deficiens_x0002_serum response factor family (Potthoff & Olson, 2007)

About Function

Enhancer function : The myocyte enhancer factor 2C gene (MEF2C), located at chromosome 5q14.3, encodes a transcription factor from the MCM1-agamous-deficiens_x0002_serum response factor family (Potthoff & Olson, 2007)
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:
The myocyte enhancer factor 2C gene (MEF2C), located at chromosome 5q14.3, encodes a transcription factor from the MCM1-agamous-deficiens_x0002_serum response factor family (Potthoff & Olson, 2007)

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
MEF2C CDO in myogenesis reactome 29
MEF2C Circadian Clock reactome 49
MEF2C ErbB1 downstream signaling pid 105
MEF2C ERK/MAPK targets reactome 17
MEF2C Notch netpath 76
MEF2C Oxidative stress response panther 23
MEF2C p38 MAPK pathway panther 31
MEF2C Regulation of nuclear SMAD2/3 signaling pid 82
MEF2C Regulation of retinoblastoma protein pid 67
MEF2C Signaling events mediated by HDAC Class II pid 58
MEF2C Signaling mediated by p38-alpha and p38-beta pid 35
MEF2C TGF_beta_Receptor netpath 220
MEF2C Transcriptional activation of mitochondrial biogenesis reactome 43
MEF2C Trk receptor signaling mediated by the MAPK pathway pid 34
MEF2C MAPK signaling pathway kegg 264
MEF2C Hs_Endochondral_Ossification_WP474_87977 wikipathways 43
MEF2C Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
MEF2C Hs_Heart_Development_WP1591_90186 wikipathways 28
MEF2C Hs_Oxidation_by_Cytochrome_P450_WP43_84102 wikipathways 14
MEF2C Hs_TGF-beta_Signaling_Pathway_WP366_90028 wikipathways 67

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs