About Enhancer

Enhancer ID: E_02_0036
Species: mouse
Position : chr14:18175266-18186392
Biosample name:
Experiment class : Low+High throughput
Enhancer type: Enhancer
Disease: Hepatocellular carcinoma
Pubmed ID:  29113912
Enhancer experiment: ChIP-seq
Enhancer experiment description: Notably, histone modification markers, including H3K4me1,H3K4me3, H3K27me3 and H3K27ac were presented at the Ang2 gene locus in liver tumor cells and were strongly colocal_x0002_ized with the two Arid1a-binding sites, suggesting an associa_x0002_tion between Arid1a binding and histone modification at the Ang2 gene locus (Fig. 4A). ChIP-qPCR analysis showed Arid1a knockdown increased the H3K27ac at the Ang2 proximal and distal regions.

About Target gene

Target gene : Ang2(Angrp,Raa3,Rnase5b),Ang2(Angrp,Raa3,Rnase5b)
Strong evidence: --
Less strong evidence: ChIP-seq,ChIP-qPCR
Target gene experiment description: Notably, histone modification markers, including H3K4me1,H3K4me3, H3K27me3 and H3K27ac were presented at the Ang2 gene locus in liver tumor cells and were strongly colocal_x0002_ized with the two Arid1a-binding sites, suggesting an associa_x0002_tion between Arid1a binding and histone modification at the Ang2 gene locus (Fig. 4A). ChIP-qPCR analysis showed Arid1a knockdown increased the H3K27ac at the Ang2 proximal and distal regions.;Notably, histone modification markers, including H3K4me1,H3K4me3, H3K27me3 and H3K27ac were presented at the Ang2 gene locus in liver tumor cells and were strongly colocal_x0002_ized with the two Arid1a-binding sites, suggesting an associa_x0002_tion between Arid1a binding and histone modification at the Ang2 gene locus (Fig. 4A). ChIP-qPCR analysis showed Arid1a knockdown increased the H3K27ac at the Ang2 proximal and distal regions.

About TF

TF name : Ep300(KAT3B,MKHK2,RSTS2,p300)Ep300(KAT3B,MKHK2,RSTS2,p300)
TF experiment: ChIP-seq,ChIP-PCR
TF experiment description: Interestingly,published ChIP-seq data also showed that p300 bound to the Ang2 gene locus, as we validated by ChIP-PCR.;Interestingly,published ChIP-seq data also showed that p300 bound to the Ang2 gene locus, as we validated by ChIP-PCR.

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:		 --

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
Ep300 Activation of anterior HOX genes in hindbrain development during early embryogenesis reactome 120
Ep300 AndrogenReceptor netpath 167
Ep300 AP-1 transcription factor network pid 71
Ep300 ATF-2 transcription factor network pid 59
Ep300 Attenuation phase reactome 28
Ep300 B-WICH complex positively regulates rRNA expression reactome 89
Ep300 BMAL1:CLOCK,NPAS2 activates circadian gene expression reactome 42
Ep300 BMP signaling in Drosophila ( BMP signaling in Drosophila ) inoh 7
Ep300 BMP signaling in Drosophila (dorsal midline) ( BMP signaling in Drosophila ) inoh 7
Ep300 BMP signaling in Drosophila (dorsolateral) ( BMP signaling in Drosophila ) inoh 7
Ep300 BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) ) inoh 34
Ep300 BMP2 signaling pathway(through Smad) ( TGF-beta_BMP Diagram(MolecularVariation) ) inoh 13
Ep300 C-MYB transcription factor network pid 87
Ep300 C. elegans Notch signaling pathway ( Notch signaling pathway Diagram ) inoh 8
Ep300 Canonical Notch signaling pathway ( Notch signaling pathway Diagram ) inoh 19
Ep300 CD209 (DC-SIGN) signaling reactome 21
Ep300 Circadian Clock reactome 49
Ep300 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants reactome 57
Ep300 Constitutive Signaling by NOTCH1 PEST Domain Mutants reactome 57
Ep300 Direct p53 effectors pid 141
Ep300 Dual incision in TC-NER reactome 63
Ep300 E2F transcription factor network pid 77
Ep300 Factors involved in megakaryocyte development and platelet production reactome 111
Ep300 Formation of TC-NER Pre-Incision Complex reactome 53
Ep300 Formation of the beta-catenin:TCF transactivating complex reactome 88
Ep300 FOXA1 transcription factor network pid 45
Ep300 FOXM1 transcription factor network pid 43
Ep300 FoxO family signaling pid 50
Ep300 Gap-filling DNA repair synthesis and ligation in TC-NER reactome 62
Ep300 Glucocorticoid receptor regulatory network pid 85
Ep300 HATs acetylate histones reactome 142
Ep300 HIF-1-alpha transcription factor network pid 67
Ep300 HIF-2-alpha transcription factor network pid 34
Ep300 Huntington disease panther 113
Ep300 IFN-gamma pathway pid 43
Ep300 IL4 netpath 75
Ep300 IL6 netpath 85
Ep300 KitReceptor netpath 104
Ep300 Leptin netpath 98
Ep300 LIF signaling pathway ( LIF signaling(JAK1 JAK2 STAT3) ) inoh 10
Ep300 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production reactome 5
Ep300 Mammalian Notch signaling pathway ( Notch signaling pathway Diagram ) inoh 15
Ep300 Notch-mediated HES/HEY network pid 48
Ep300 Notch netpath 76
Ep300 Notch signaling pathway pid 58
Ep300 NOTCH1 Intracellular Domain Regulates Transcription reactome 47
Ep300 NOTCH2 intracellular domain regulates transcription reactome 12
Ep300 p53 pathway panther 39
Ep300 p53 pathway pid 59
Ep300 p73 transcription factor network pid 80
Ep300 Polo-like kinase mediated events reactome 16
Ep300 PPARA activates gene expression reactome 113
Ep300 Pre-NOTCH Transcription and Translation reactome 29
Ep300 Prolactin netpath 105
Ep300 Regulation of Androgen receptor activity pid 54
Ep300 Regulation of gene expression by Hypoxia-inducible Factor reactome 10
Ep300 Regulation of nuclear beta catenin signaling and target gene transcription pid 80
Ep300 Regulation of nuclear SMAD2/3 signaling pid 82
Ep300 Regulation of retinoblastoma protein pid 67
Ep300 Regulation of TP53 Activity through Acetylation reactome 23
Ep300 Regulation of TP53 Activity through Methylation reactome 19
Ep300 Retinoic acid receptors-mediated signaling pid 30
Ep300 Role of Calcineurin-dependent NFAT signaling in lymphocytes pid 54
Ep300 RORA activates gene expression reactome 27
Ep300 Signaling events mediated by HDAC Class I pid 89
Ep300 Signaling events mediated by HDAC Class III pid 41
Ep300 Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) inoh 47
Ep300 Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) inoh 47
Ep300 Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) inoh 47
Ep300 Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) inoh 47
Ep300 Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 47
Ep300 Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) inoh 47
Ep300 Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 19
Ep300 TGF-beta signaling pathway panther 88
Ep300 TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) ) inoh 51
Ep300 TGF_beta_Receptor netpath 220
Ep300 TNFalpha netpath 274
Ep300 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest reactome 18
Ep300 TRAF3-dependent IRF activation pathway reactome 14
Ep300 TRAF6 mediated IRF7 activation reactome 33
Ep300 Transcription-Coupled Nucleotide Excision Repair (TC-NER) reactome 44
Ep300 Transcription regulation by bZIP transcription factor panther 42
Ep300 Transcriptional regulation of white adipocyte differentiation reactome 79
Ep300 Validated nuclear estrogen receptor alpha network pid 65
Ep300 Validated targets of C-MYC transcriptional activation pid 80
Ep300 Validated targets of C-MYC transcriptional repression pid 63
Ep300 Validated transcriptional targets of AP1 family members Fra1 and Fra2 pid 37
Ep300 Validated transcriptional targets of TAp63 isoforms pid 54
Ep300 Wnt signaling pathway panther 250
Ep300 Cell cycle kegg 124
Ep300 Wnt signaling pathway kegg 135
Ep300 Notch signaling pathway kegg 44
Ep300 TGF-beta signaling pathway kegg 82
Ep300 Adherens junction kegg 70
Ep300 Jak-STAT signaling pathway kegg 149
Ep300 Long-term potentiation kegg 67
Ep300 Melanogenesis kegg 100
Ep300 Huntington's disease kegg 182
Ep300 Pathways in cancer kegg 321
Ep300 Renal cell carcinoma kegg 65
Ep300 Prostate cancer kegg 85
Ep300 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
Ep300 Hs_Signaling_Pathways_in_Glioblastoma_WP2261_89520 wikipathways 16
Ep300 Hs_Kit_receptor_signaling_pathway_WP304_78799 wikipathways 46
Ep300 Hs_Notch_Signaling_Pathway_WP61_78592 wikipathways 16
Ep300 Activation of anterior HOX genes in hindbrain development during early embryogenesis reactome 120
Ep300 AndrogenReceptor netpath 167
Ep300 AP-1 transcription factor network pid 71
Ep300 ATF-2 transcription factor network pid 59
Ep300 Attenuation phase reactome 28
Ep300 B-WICH complex positively regulates rRNA expression reactome 89
Ep300 BMAL1:CLOCK,NPAS2 activates circadian gene expression reactome 42
Ep300 BMP signaling in Drosophila ( BMP signaling in Drosophila ) inoh 7
Ep300 BMP signaling in Drosophila (dorsal midline) ( BMP signaling in Drosophila ) inoh 7
Ep300 BMP signaling in Drosophila (dorsolateral) ( BMP signaling in Drosophila ) inoh 7
Ep300 BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) ) inoh 34
Ep300 BMP2 signaling pathway(through Smad) ( TGF-beta_BMP Diagram(MolecularVariation) ) inoh 13
Ep300 C-MYB transcription factor network pid 87
Ep300 C. elegans Notch signaling pathway ( Notch signaling pathway Diagram ) inoh 8
Ep300 Canonical Notch signaling pathway ( Notch signaling pathway Diagram ) inoh 19
Ep300 CD209 (DC-SIGN) signaling reactome 21
Ep300 Circadian Clock reactome 49
Ep300 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants reactome 57
Ep300 Constitutive Signaling by NOTCH1 PEST Domain Mutants reactome 57
Ep300 Direct p53 effectors pid 141
Ep300 Dual incision in TC-NER reactome 63
Ep300 E2F transcription factor network pid 77
Ep300 Factors involved in megakaryocyte development and platelet production reactome 111
Ep300 Formation of TC-NER Pre-Incision Complex reactome 53
Ep300 Formation of the beta-catenin:TCF transactivating complex reactome 88
Ep300 FOXA1 transcription factor network pid 45
Ep300 FOXM1 transcription factor network pid 43
Ep300 FoxO family signaling pid 50
Ep300 Gap-filling DNA repair synthesis and ligation in TC-NER reactome 62
Ep300 Glucocorticoid receptor regulatory network pid 85
Ep300 HATs acetylate histones reactome 142
Ep300 HIF-1-alpha transcription factor network pid 67
Ep300 HIF-2-alpha transcription factor network pid 34
Ep300 Huntington disease panther 113
Ep300 IFN-gamma pathway pid 43
Ep300 IL4 netpath 75
Ep300 IL6 netpath 85
Ep300 KitReceptor netpath 104
Ep300 Leptin netpath 98
Ep300 LIF signaling pathway ( LIF signaling(JAK1 JAK2 STAT3) ) inoh 10
Ep300 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production reactome 5
Ep300 Mammalian Notch signaling pathway ( Notch signaling pathway Diagram ) inoh 15
Ep300 Notch-mediated HES/HEY network pid 48
Ep300 Notch netpath 76
Ep300 Notch signaling pathway pid 58
Ep300 NOTCH1 Intracellular Domain Regulates Transcription reactome 47
Ep300 NOTCH2 intracellular domain regulates transcription reactome 12
Ep300 p53 pathway panther 39
Ep300 p53 pathway pid 59
Ep300 p73 transcription factor network pid 80
Ep300 Polo-like kinase mediated events reactome 16
Ep300 PPARA activates gene expression reactome 113
Ep300 Pre-NOTCH Transcription and Translation reactome 29
Ep300 Prolactin netpath 105
Ep300 Regulation of Androgen receptor activity pid 54
Ep300 Regulation of gene expression by Hypoxia-inducible Factor reactome 10
Ep300 Regulation of nuclear beta catenin signaling and target gene transcription pid 80
Ep300 Regulation of nuclear SMAD2/3 signaling pid 82
Ep300 Regulation of retinoblastoma protein pid 67
Ep300 Regulation of TP53 Activity through Acetylation reactome 23
Ep300 Regulation of TP53 Activity through Methylation reactome 19
Ep300 Retinoic acid receptors-mediated signaling pid 30
Ep300 Role of Calcineurin-dependent NFAT signaling in lymphocytes pid 54
Ep300 RORA activates gene expression reactome 27
Ep300 Signaling events mediated by HDAC Class I pid 89
Ep300 Signaling events mediated by HDAC Class III pid 41
Ep300 Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) inoh 47
Ep300 Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) inoh 47
Ep300 Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) inoh 47
Ep300 Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) inoh 47
Ep300 Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 47
Ep300 Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) inoh 47
Ep300 Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 19
Ep300 TGF-beta signaling pathway panther 88
Ep300 TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) ) inoh 51
Ep300 TGF_beta_Receptor netpath 220
Ep300 TNFalpha netpath 274
Ep300 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest reactome 18
Ep300 TRAF3-dependent IRF activation pathway reactome 14
Ep300 TRAF6 mediated IRF7 activation reactome 33
Ep300 Transcription-Coupled Nucleotide Excision Repair (TC-NER) reactome 44
Ep300 Transcription regulation by bZIP transcription factor panther 42
Ep300 Transcriptional regulation of white adipocyte differentiation reactome 79
Ep300 Validated nuclear estrogen receptor alpha network pid 65
Ep300 Validated targets of C-MYC transcriptional activation pid 80
Ep300 Validated targets of C-MYC transcriptional repression pid 63
Ep300 Validated transcriptional targets of AP1 family members Fra1 and Fra2 pid 37
Ep300 Validated transcriptional targets of TAp63 isoforms pid 54
Ep300 Wnt signaling pathway panther 250
Ep300 Cell cycle kegg 124
Ep300 Wnt signaling pathway kegg 135
Ep300 Notch signaling pathway kegg 44
Ep300 TGF-beta signaling pathway kegg 82
Ep300 Adherens junction kegg 70
Ep300 Jak-STAT signaling pathway kegg 149
Ep300 Long-term potentiation kegg 67
Ep300 Melanogenesis kegg 100
Ep300 Huntington's disease kegg 182
Ep300 Pathways in cancer kegg 321
Ep300 Renal cell carcinoma kegg 65
Ep300 Prostate cancer kegg 85
Ep300 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
Ep300 Hs_Signaling_Pathways_in_Glioblastoma_WP2261_89520 wikipathways 16
Ep300 Hs_Kit_receptor_signaling_pathway_WP304_78799 wikipathways 46
Ep300 Hs_Notch_Signaling_Pathway_WP61_78592 wikipathways 16

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs