About Enhancer
| Enhancer ID: | E_02_0168 |
| Species: | mouse |
| Position : | chr12:107873350-107875350   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 31653691 |
| Enhancer experiment: | Flow cytometry,Western blot,PCR |
| Enhancer experiment description: | To com_x0002_pare the molecular mechanisms through which Bcl11b controls cell typespecific gene regulation in the two contexts, we first examined the DNA binding patterns of Bcl11b across the genome in pro-T cells with those in ILC2 cells. |
About Target gene
| Target gene : | Bcl11b(ATL1,ATL1-alpha,ATL1-beta,ATL1-delta,ATL1-gamma,CTIP-2,CTIP2,IDDFSTA,IMD49,RIT1,ZNF856B,hRIT1-alpha),Runx1(BTEB2,CKLF,IKLF),GATA3(Gata-3,jal) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | To com_x0002_pare the molecular mechanisms through which Bcl11b controls cell typespecific gene regulation in the two contexts, we first examined the DNA binding patterns of Bcl11b across the genome in pro-T cells with those in ILC2 cells.;Thus, globally, Runx1, Runx3, and Bcl11b binding sites across the genome were often coincident within a cell type, but differed markedly between pro-T and ILC2 contexts.;These results show sharp lineagespecific binding differences both for the Runx factors, usually co-recruited with Bcl11b, and for GATA3, often recruited inde pendently of Bcl11b. They also indicate a likely role for a bZIP family member in defining ILC2-specific occupancy sites of Bcl11b, Runx factors, and GATA3 |
About TF
| TF name : | -- |
| TF experiment: | Flow cytometry,Western blot,PCR |
| TF experiment description: | To com_x0002_pare the molecular mechanisms through which Bcl11b controls cell typespecific gene regulation in the two contexts, we first examined the DNA binding patterns of Bcl11b across the genome in pro-T cells with those in ILC2 cells.;Thus, globally, Runx1, Runx3, and Bcl11b binding sites across the genome were often coincident within a cell type, but differed markedly between pro-T and ILC2 contexts.;These results show sharp lineagespecific binding differences both for the Runx factors, usually co-recruited with Bcl11b, and for GATA3, often recruited inde pendently of Bcl11b. They also indicate a likely role for a bZIP family member in defining ILC2-specific occupancy sites of Bcl11b, Runx factors, and GATA3 |
About Function
| Enhancer function : | To com_x0002_pare the molecular mechanisms through which Bcl11b controls cell typespecific gene regulation in the two contexts, we first examined the DNA binding patterns of Bcl11b across the genome in pro-T cells with those in ILC2 cells. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
To com_x0002_pare the molecular mechanisms through which Bcl11b controls cell typespecific gene regulation in the two contexts, we first examined the DNA binding patterns of Bcl11b across the genome in pro-T cells with those in ILC2 cells. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene