About Enhancer
| Enhancer ID: | E_02_0190 |
| Species: | mouse |
| Position : | chr4:53777000-53779000   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 31591447 |
| Enhancer experiment: | Flow cytometry,PCR |
| Enhancer experiment description: | We first analyzed gene expression dynamics during the development of each lineage (Fig. 1be; Supplementary informa_x0002_tion, Table S2) and found that expression of ectodermal genes (e.g., Tal2 and Lhx5), mesendodermal genes |
About Target gene
| Target gene : | Tal2,Lhx5,Sox2(ANOP3,MCOPS3),Mesp1(bHLHc5) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | We first analyzed gene expression dynamics during the development of each lineage (Fig. 1be; Supplementary informa_x0002_tion, Table S2) and found that expression of ectodermal genes (e.g., Tal2 and Lhx5), mesendodermal genes;We first analyzed gene expression dynamics during the development of each lineage (Fig. 1be; Supplementary informa_x0002_tion, Table S2) and found that expression of ectodermal genes (e.g., Tal2 and Lhx5), mesendodermal genes;These gastrula-specific enhancer bins were enriched near genes that are related to embryonic pattern formation, gastrulation and primary germ layer specification, and are highly expressed at the gastrulation stage, such as Sox2, Eomes and Mesp1 (Fig. 5be).;These gastrula-specific enhancer bins were enriched near genes that are related to embryonic pattern formation, gastrulation and primary germ layer specification, and are highly expressed at the gastrulation stage, such as Sox2, Eomes and Mesp1 (Fig. 5be). |
About TF
| TF name : | -- |
| TF experiment: | Flow cytometry,PCR |
| TF experiment description: | We first analyzed gene expression dynamics during the development of each lineage (Fig. 1be; Supplementary informa_x0002_tion, Table S2) and found that expression of ectodermal genes (e.g., Tal2 and Lhx5), mesendodermal genes;We first analyzed gene expression dynamics during the development of each lineage (Fig. 1be; Supplementary informa_x0002_tion, Table S2) and found that expression of ectodermal genes (e.g., Tal2 and Lhx5), mesendodermal genes;These gastrula-specific enhancer bins were enriched near genes that are related to embryonic pattern formation, gastrulation and primary germ layer specification, and are highly expressed at the gastrulation stage, such as Sox2, Eomes and Mesp1 (Fig. 5be).;These gastrula-specific enhancer bins were enriched near genes that are related to embryonic pattern formation, gastrulation and primary germ layer specification, and are highly expressed at the gastrulation stage, such as Sox2, Eomes and Mesp1 (Fig. 5be). |
About Function
| Enhancer function : | We first analyzed gene expression dynamics during the development of each lineage (Fig. 1be; Supplementary informa_x0002_tion, Table S2) and found that expression of ectodermal genes (e.g., Tal2 and Lhx5), mesendodermal genes |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
We first analyzed gene expression dynamics during the development of each lineage (Fig. 1be; Supplementary informa_x0002_tion, Table S2) and found that expression of ectodermal genes (e.g., Tal2 and Lhx5), mesendodermal genes |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene