About Enhancer
| Enhancer ID: | E_02_0222 |
| Species: | human |
| Position : | chr21:45491095-45493095   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Leukemia |
| Pubmed ID: | 31511694 |
| Enhancer experiment: | Western blot,PCR,Flow cytometry |
| Enhancer experiment description: | SLC19A1 was one of the most significant hits in both screens. SLC19A1 is a folateorganic phosphate antiporter that transports folates, structurally similar antifolates and a variety of organic phos_x0002_phates encompassing (among others) thiamine derivatives and nucle_x0002_otides15,16. |
About Target gene
| Target gene : | SLC19A1,CCL5,IRF3 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | SLC19A1 was one of the most significant hits in both screens. SLC19A1 is a folateorganic phosphate antiporter that transports folates, structurally similar antifolates and a variety of organic phos_x0002_phates encompassing (among others) thiamine derivatives and nucle_x0002_otides15,16.;SLC19A1 depletionsimilar to depletion of IRF3 or STINGalso inhibited CDN-induced expression of direct downstream target genes in the STING pathway, including IFNB1 and the chemokine genes CCL5 and CXCL1021,22 (Fig. 2c, Extended Data Fig. 3gi).;Protein levels of STING, TBK1 and IRF3 were unaltered in SLC19A1- depleted cells |
About TF
| TF name : | -- |
| TF experiment: | Western blot,PCR,Flow cytometry |
| TF experiment description: | SLC19A1 was one of the most significant hits in both screens. SLC19A1 is a folateorganic phosphate antiporter that transports folates, structurally similar antifolates and a variety of organic phos_x0002_phates encompassing (among others) thiamine derivatives and nucle_x0002_otides15,16.;SLC19A1 depletionsimilar to depletion of IRF3 or STINGalso inhibited CDN-induced expression of direct downstream target genes in the STING pathway, including IFNB1 and the chemokine genes CCL5 and CXCL1021,22 (Fig. 2c, Extended Data Fig. 3gi).;Protein levels of STING, TBK1 and IRF3 were unaltered in SLC19A1- depleted cells |
About Function
| Enhancer function : | SLC19A1 was one of the most significant hits in both screens. SLC19A1 is a folateorganic phosphate antiporter that transports folates, structurally similar antifolates and a variety of organic phos_x0002_phates encompassing (among others) thiamine derivatives and nucle_x0002_otides15,16. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
SLC19A1 was one of the most significant hits in both screens. SLC19A1 is a folateorganic phosphate antiporter that transports folates, structurally similar antifolates and a variety of organic phos_x0002_phates encompassing (among others) thiamine derivatives and nucle_x0002_otides15,16. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene