About Enhancer
| Enhancer ID: |
E_02_0228 |
| Species: |
human |
| Position :
|
chr7:148803986-148805986
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
-- |
| Pubmed ID: |
31487061
|
| Enhancer experiment: |
Western blot, PCR, immunofluorescence staining |
| Enhancer experiment description: |
EZH2 plays an important role in bone homeostasis and the use of the small molecule inhibitor GSK126 (a potent and highly selective EZH2 methyltransferase inhibitor(22)) exhibited promising bone protecting effects in several osteoporotic/inflam_x0002_matory and malignant osteolytic bone pathologies.(2327) |
About Target gene
| Target gene : |
EZH2 |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
EZH2 plays an important role in bone homeostasis and the use of the small molecule inhibitor GSK126 (a potent and highly selective EZH2 methyltransferase inhibitor(22)) exhibited promising bone protecting effects in several osteoporotic/inflam_x0002_matory and malignant osteolytic bone pathologies.(2327) |
About TF
| TF name : |
-- |
| TF experiment: |
Western blot,PCR,?????? |
| TF experiment description: |
EZH2 plays an important role in bone homeostasis and the use of the small molecule inhibitor GSK126 (a potent and highly selective EZH2 methyltransferase inhibitor(22)) exhibited promising bone protecting effects in several osteoporotic/inflam_x0002_matory and malignant osteolytic bone pathologies.(2327) |
About Function
| Enhancer function : |
EZH2 plays an important role in bone homeostasis and the use of the small molecule inhibitor GSK126 (a potent and highly selective EZH2 methyltransferase inhibitor(22)) exhibited promising bone protecting effects in several osteoporotic/inflam_x0002_matory and malignant osteolytic bone pathologies.(2327) |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
EZH2 plays an important role in bone homeostasis and the use of the small molecule inhibitor GSK126 (a potent and highly selective EZH2 methyltransferase inhibitor(22)) exhibited promising bone protecting effects in several osteoporotic/inflam_x0002_matory and malignant osteolytic bone pathologies.(2327) |
About SNP
Upstream Pathway Annotation of TF
| GeneName |
Pathway Name |
Source |
Gene Number |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs