About Enhancer
| Enhancer ID: | E_02_0280 |
| Species: | mouse |
| Position : | chr11:98246620-98248620   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Cholesterol |
| Pubmed ID: | 29908180 |
| Enhancer experiment: | Oil red-O staining,Small interfering RNA,Quantitative real-time PCR,Protein isolation,western blot,transfection |
| Enhancer experiment description: | Moreover, Stard3 silencing reduced the expression of peroxisome proliferator-activated receptor-? (PPAR?) and CCAAT/enhancer binding protein (C/EBP)? in 3T3- L1 cells. In conclusion, Stard3 enhanced the adipogenesis of preadipocytes by enhancement of cholesterol redistribution to the mitochondrial, increasing mitochondrial ROS production. These results suggest that Stard3 is an essential factor for the 3T3-L1 cells' differentiation. |
About Target gene
| Target gene : | Stard3 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Moreover, Stard3 silencing reduced the expression of peroxisome proliferator-activated receptor-? (PPAR?) and CCAAT/enhancer binding protein (C/EBP)? in 3T3- L1 cells. In conclusion, Stard3 enhanced the adipogenesis of preadipocytes by enhancement of cholesterol redistribution to the mitochondrial, increasing mitochondrial ROS production. These results suggest that Stard3 is an essential factor for the 3T3-L1 cells' differentiation. |
About TF
| TF name : | -- |
| TF experiment: | Oil red-O staining,Small interfering RNA,Quantitative real-time PCR,Protein isolation,western blot,transfection |
| TF experiment description: | Moreover, Stard3 silencing reduced the expression of peroxisome proliferator-activated receptor-? (PPAR?) and CCAAT/enhancer binding protein (C/EBP)? in 3T3- L1 cells. In conclusion, Stard3 enhanced the adipogenesis of preadipocytes by enhancement of cholesterol redistribution to the mitochondrial, increasing mitochondrial ROS production. These results suggest that Stard3 is an essential factor for the 3T3-L1 cells' differentiation. |
About Function
| Enhancer function : | Moreover, Stard3 silencing reduced the expression of peroxisome proliferator-activated receptor-? (PPAR?) and CCAAT/enhancer binding protein (C/EBP)? in 3T3- L1 cells. In conclusion, Stard3 enhanced the adipogenesis of preadipocytes by enhancement of cholesterol redistribution to the mitochondrial, increasing mitochondrial ROS production. These results suggest that Stard3 is an essential factor for the 3T3-L1 cells' differentiation. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Moreover, Stard3 silencing reduced the expression of peroxisome proliferator-activated receptor-? (PPAR?) and CCAAT/enhancer binding protein (C/EBP)? in 3T3- L1 cells. In conclusion, Stard3 enhanced the adipogenesis of preadipocytes by enhancement of cholesterol redistribution to the mitochondrial, increasing mitochondrial ROS production. These results suggest that Stard3 is an essential factor for the 3T3-L1 cells' differentiation. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene