About Enhancer
| Enhancer ID: | E_02_0291 |
| Species: | human |
| Position : | chr11:102833101-102835101   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Disc degeneration |
| Pubmed ID: | 29852820 |
| Enhancer experiment: | Dual Luciferase Reporter Assay, real-time PCR,Western Blot,MRI,HE staining,collagen II immunochemistry,transgenic mice,Histology,immunohistochemistry,C/EBP? knockdown,transfection,PCR |
| Enhancer experiment description: | miR-155 is a sustainable factor for intervertebral disk and suppresses the expression of catabolic genes induced by TNF-? and IL-1? by targeting C/EBP? in rat NP cells. |
About Target gene
| Target gene : | MMP3,GAPDH |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | miR-155 is a sustainable factor for intervertebral disk and suppresses the expression of catabolic genes induced by TNF-? and IL-1? by targeting C/EBP? in rat NP cells.;miR-155 is a sustainable factor for intervertebral disk and suppresses the expression of catabolic genes induced by TNF-? and IL-1? by targeting C/EBP? in rat NP cells. |
About TF
| TF name : | -- |
| TF experiment: | Dual Luciferase Reporter Assay, real-time PCR,Western Blot,MRI,HE staining,collagen II immunochemistry,transgenic mice,Histology,immunohistochemistry,C/EBP? knockdown,transfection,PCR |
| TF experiment description: | miR-155 is a sustainable factor for intervertebral disk and suppresses the expression of catabolic genes induced by TNF-? and IL-1? by targeting C/EBP? in rat NP cells.;miR-155 is a sustainable factor for intervertebral disk and suppresses the expression of catabolic genes induced by TNF-? and IL-1? by targeting C/EBP? in rat NP cells. |
About Function
| Enhancer function : | miR-155 is a sustainable factor for intervertebral disk and suppresses the expression of catabolic genes induced by TNF-? and IL-1? by targeting C/EBP? in rat NP cells. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
miR-155 is a sustainable factor for intervertebral disk and suppresses the expression of catabolic genes induced by TNF-? and IL-1? by targeting C/EBP? in rat NP cells. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene