About Enhancer
| Enhancer ID: | E_02_0314 |
| Species: | mouse |
| Position : | chr1:52156183-52158183   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Multiple organ dysfunction syndrome (mods) |
| Pubmed ID: | 29749505 |
| Enhancer experiment: | Pathway enrichment analysis |
| Enhancer experiment description: | A total of 18 DEGs were common among lung, liver and kidney tissues, including CCAAT/enhancer binding protein ? (Cebpb) and olfactomedin?like 1 (Olfml1). Cebpb modulated various other DEGs, such as Cxcl1, and Olfml1 was regulated by Stat5A. These genes and pathways may serve roles in the progression of MODS and may be considered to be potential therapy targets for MODS. |
About Target gene
| Target gene : | Stat1(CANDF7,IMD31A,IMD31B,IMD31C,ISGF-3,STAT91),Cebpb(C/EBPbeta,CRP2,IL-6DBP,LAP,LIP,NF-IL6,NF-M,Nfil6),Olfml1,Cxcl1,Cxcl10 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | A total of 18 DEGs were common among lung, liver and kidney tissues, including CCAAT/enhancer binding protein ? (Cebpb) and olfactomedin?like 1 (Olfml1). Cebpb modulated various other DEGs, such as Cxcl1, and Olfml1 was regulated by Stat5A. These genes and pathways may serve roles in the progression of MODS and may be considered to be potential therapy targets for MODS.;A total of 18 DEGs were common among lung, liver and kidney tissues, including CCAAT/enhancer binding protein ? (Cebpb) and olfactomedin?like 1 (Olfml1). Cebpb modulated various other DEGs, such as Cxcl1, and Olfml1 was regulated by Stat5A. These genes and pathways may serve roles in the progression of MODS and may be considered to be potential therapy targets for MODS.;A total of 18 DEGs were common among lung, liver and kidney tissues, including CCAAT/enhancer binding protein ? (Cebpb) and olfactomedin?like 1 (Olfml1). Cebpb modulated various other DEGs, such as Cxcl1, and Olfml1 was regulated by Stat5A. These genes and pathways may serve roles in the progression of MODS and may be considered to be potential therapy targets for MODS.;A total of 18 DEGs were common among lung, liver and kidney tissues, including CCAAT/enhancer binding protein ? (Cebpb) and olfactomedin?like 1 (Olfml1). Cebpb modulated various other DEGs, such as Cxcl1, and Olfml1 was regulated by Stat5A. These genes and pathways may serve roles in the progression of MODS and may be considered to be potential therapy targets for MODS.;A total of 18 DEGs were common among lung, liver and kidney tissues, including CCAAT/enhancer binding protein ? (Cebpb) and olfactomedin?like 1 (Olfml1). Cebpb modulated various other DEGs, such as Cxcl1, and Olfml1 was regulated by Stat5A. These genes and pathways may serve roles in the progression of MODS and may be considered to be potential therapy targets for MODS. |
About TF
| TF name : | -- |
| TF experiment: | Pathway enrichment analysis |
| TF experiment description: | A total of 18 DEGs were common among lung, liver and kidney tissues, including CCAAT/enhancer binding protein ? (Cebpb) and olfactomedin?like 1 (Olfml1). Cebpb modulated various other DEGs, such as Cxcl1, and Olfml1 was regulated by Stat5A. These genes and pathways may serve roles in the progression of MODS and may be considered to be potential therapy targets for MODS.;A total of 18 DEGs were common among lung, liver and kidney tissues, including CCAAT/enhancer binding protein ? (Cebpb) and olfactomedin?like 1 (Olfml1). Cebpb modulated various other DEGs, such as Cxcl1, and Olfml1 was regulated by Stat5A. These genes and pathways may serve roles in the progression of MODS and may be considered to be potential therapy targets for MODS.;A total of 18 DEGs were common among lung, liver and kidney tissues, including CCAAT/enhancer binding protein ? (Cebpb) and olfactomedin?like 1 (Olfml1). Cebpb modulated various other DEGs, such as Cxcl1, and Olfml1 was regulated by Stat5A. These genes and pathways may serve roles in the progression of MODS and may be considered to be potential therapy targets for MODS.;A total of 18 DEGs were common among lung, liver and kidney tissues, including CCAAT/enhancer binding protein ? (Cebpb) and olfactomedin?like 1 (Olfml1). Cebpb modulated various other DEGs, such as Cxcl1, and Olfml1 was regulated by Stat5A. These genes and pathways may serve roles in the progression of MODS and may be considered to be potential therapy targets for MODS.;A total of 18 DEGs were common among lung, liver and kidney tissues, including CCAAT/enhancer binding protein ? (Cebpb) and olfactomedin?like 1 (Olfml1). Cebpb modulated various other DEGs, such as Cxcl1, and Olfml1 was regulated by Stat5A. These genes and pathways may serve roles in the progression of MODS and may be considered to be potential therapy targets for MODS. |
About Function
| Enhancer function : | A total of 18 DEGs were common among lung, liver and kidney tissues, including CCAAT/enhancer binding protein ? (Cebpb) and olfactomedin?like 1 (Olfml1). Cebpb modulated various other DEGs, such as Cxcl1, and Olfml1 was regulated by Stat5A. These genes and pathways may serve roles in the progression of MODS and may be considered to be potential therapy targets for MODS. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
A total of 18 DEGs were common among lung, liver and kidney tissues, including CCAAT/enhancer binding protein ? (Cebpb) and olfactomedin?like 1 (Olfml1). Cebpb modulated various other DEGs, such as Cxcl1, and Olfml1 was regulated by Stat5A. These genes and pathways may serve roles in the progression of MODS and may be considered to be potential therapy targets for MODS. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene