About Enhancer
| Enhancer ID: | E_02_0330 |
| Species: | human |
| Position : | chrX:103771498-103773498   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Human x-linked inherited disorders |
| Pubmed ID: | 29683207 |
| Enhancer experiment: | Transgenic mice,qRT-PCR, b-galactosidase histochemistry,b-galactosidase enzyme assay,Combined X-gal staining,immunohistochemistry,Southern blot, |
| Enhancer experiment description: | These results demonstrate for the first time that the wmN1 enhancer region: (1) is functional in hPLP1; (2) works in collaboration with its native promoter-not just a basal heterologous promoter; (3) is required for high levels of hPLP1 gene activity; (4) has a broader effect, both spatially and temporally, than originally projected with mPlp1. |
About Target gene
| Target gene : | PLP1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | These results demonstrate for the first time that the wmN1 enhancer region: (1) is functional in hPLP1; (2) works in collaboration with its native promoter-not just a basal heterologous promoter; (3) is required for high levels of hPLP1 gene activity; (4) has a broader effect, both spatially and temporally, than originally projected with mPlp1. |
About TF
| TF name : | -- |
| TF experiment: | Transgenic mice,qRT-PCR, b-galactosidase histochemistry,b-galactosidase enzyme assay,Combined X-gal staining,immunohistochemistry,Southern blot, |
| TF experiment description: | These results demonstrate for the first time that the wmN1 enhancer region: (1) is functional in hPLP1; (2) works in collaboration with its native promoter-not just a basal heterologous promoter; (3) is required for high levels of hPLP1 gene activity; (4) has a broader effect, both spatially and temporally, than originally projected with mPlp1. |
About Function
| Enhancer function : | These results demonstrate for the first time that the wmN1 enhancer region: (1) is functional in hPLP1; (2) works in collaboration with its native promoter-not just a basal heterologous promoter; (3) is required for high levels of hPLP1 gene activity; (4) has a broader effect, both spatially and temporally, than originally projected with mPlp1. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
These results demonstrate for the first time that the wmN1 enhancer region: (1) is functional in hPLP1; (2) works in collaboration with its native promoter-not just a basal heterologous promoter; (3) is required for high levels of hPLP1 gene activity; (4) has a broader effect, both spatially and temporally, than originally projected with mPlp1. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene