About Enhancer
| Enhancer ID: | E_02_0344 |
| Species: | human |
| Position : | chr8:127732819-127734819   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Prostate cancer |
| Pubmed ID: | 32617979 |
| Enhancer experiment: | RNA seq,ChIP assay,Immunohistochemistry, |
| Enhancer experiment description: | Overexpression of KDM4B promoted recruitment of AR to the c-Myc (MYC) gene enhancer and induced H3K10 demethylation, increasing AR-dependent transcription of c-Myc mRNA, which regulates the sensitivity to next generation AR-targeted therapy. |
About Target gene
| Target gene : | MYC(MRTLC,bHLHe39,c-Myc) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Overexpression of KDM4B promoted recruitment of AR to the c-Myc (MYC) gene enhancer and induced H3K10 demethylation, increasing AR-dependent transcription of c-Myc mRNA, which regulates the sensitivity to next generation AR-targeted therapy. |
About TF
| TF name : | -- |
| TF experiment: | RNA seq,ChIP assay,Immunohistochemistry, |
| TF experiment description: | Overexpression of KDM4B promoted recruitment of AR to the c-Myc (MYC) gene enhancer and induced H3K10 demethylation, increasing AR-dependent transcription of c-Myc mRNA, which regulates the sensitivity to next generation AR-targeted therapy. |
About Function
| Enhancer function : | Overexpression of KDM4B promoted recruitment of AR to the c-Myc (MYC) gene enhancer and induced H3K10 demethylation, increasing AR-dependent transcription of c-Myc mRNA, which regulates the sensitivity to next generation AR-targeted therapy. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Overexpression of KDM4B promoted recruitment of AR to the c-Myc (MYC) gene enhancer and induced H3K10 demethylation, increasing AR-dependent transcription of c-Myc mRNA, which regulates the sensitivity to next generation AR-targeted therapy. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene