About Enhancer
| Enhancer ID: |
E_02_0372 |
| Species: |
human |
| Position :
|
chr5:36149144-36151144
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
Acute myeloid leukemia |
| Pubmed ID: |
32622946
|
| Enhancer experiment: |
Western blot?Co-immunoprecipitation?Immunophenotyping analysis?flow cytometer?Quantitative real-time PCR |
| Enhancer experiment description: |
Using Estradiol-inducible K562-C/EBP?-ER cells as yet another model of granulocytic differentiation, we further confirmed that SKP2 overexpression indeed inhibits granulocytic differentiation by mitigating C/EBP? stability. |
About Target gene
| Target gene : |
SKP2 |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
Using Estradiol-inducible K562-C/EBP?-ER cells as yet another model of granulocytic differentiation, we further confirmed that SKP2 overexpression indeed inhibits granulocytic differentiation by mitigating C/EBP? stability. |
About TF
| TF name : |
-- |
| TF experiment: |
Western blot?Co-immunoprecipitation?Immunophenotyping analysis?flow cytometer?Quantitative real-time PCR |
| TF experiment description: |
Using Estradiol-inducible K562-C/EBP?-ER cells as yet another model of granulocytic differentiation, we further confirmed that SKP2 overexpression indeed inhibits granulocytic differentiation by mitigating C/EBP? stability. |
About Function
| Enhancer function : |
Using Estradiol-inducible K562-C/EBP?-ER cells as yet another model of granulocytic differentiation, we further confirmed that SKP2 overexpression indeed inhibits granulocytic differentiation by mitigating C/EBP? stability. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
Using Estradiol-inducible K562-C/EBP?-ER cells as yet another model of granulocytic differentiation, we further confirmed that SKP2 overexpression indeed inhibits granulocytic differentiation by mitigating C/EBP? stability. |
About SNP
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs