About Enhancer
| Enhancer ID: | E_02_0387 |
| Species: | human |
| Position : | chr9:2618555-2620555   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Cardiovascular disease |
| Pubmed ID: | 30445632 |
| Enhancer experiment: | Transcriptional reporter and EMSAs? DNA affinity pull-down assay?dual-luciferase reporter assay?DNA-affinity capture assay? tandem mass spectrometry analysis |
| Enhancer experiment description: | An enhancer of VLDLR expression and suggest that altered binding of one or more factors bound to rs3780181 alleles decreases enhancer activity and reduces at least VLDLR expression, leading to increased TC and LDL-C. |
About Target gene
| Target gene : | VLDLR |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | An enhancer of VLDLR expression and suggest that altered binding of one or more factors bound to rs3780181 alleles decreases enhancer activity and reduces at least VLDLR expression, leading to increased TC and LDL-C. |
About TF
| TF name : | -- |
| TF experiment: | Transcriptional reporter and EMSAs? DNA affinity pull-down assay?dual-luciferase reporter assay?DNA-affinity capture assay? tandem mass spectrometry analysis |
| TF experiment description: | An enhancer of VLDLR expression and suggest that altered binding of one or more factors bound to rs3780181 alleles decreases enhancer activity and reduces at least VLDLR expression, leading to increased TC and LDL-C. |
About Function
| Enhancer function : | An enhancer of VLDLR expression and suggest that altered binding of one or more factors bound to rs3780181 alleles decreases enhancer activity and reduces at least VLDLR expression, leading to increased TC and LDL-C. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
An enhancer of VLDLR expression and suggest that altered binding of one or more factors bound to rs3780181 alleles decreases enhancer activity and reduces at least VLDLR expression, leading to increased TC and LDL-C. |
About SNP
| SNP ID: | rs3780181 |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene