About Enhancer
| Enhancer ID: | E_02_0400 |
| Species: | mouse |
| Position : | chrX:7437025-7439025   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Inflammation |
| Pubmed ID: | 30349541 |
| Enhancer experiment: | Retroviral transduction,Intracellular staining,Quantitative real-time PCR,Chromatin immunoprecipitation assays,Bisulfite sequencing,Electrophoretic mobility shift assay |
| Enhancer experiment description: | CCAAT/enhancer-binding protein (C/EBP) functions as a safeguard that enhances Treg cell generation by dampening the inhibitory effect of IFN-c and IL-4 on Foxp3 expression. These results establish C/EBP as a new molecular target for enhancing the formation and stability of Treg cells in inflammatory environments. |
About Target gene
| Target gene : | Foxp3 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | CCAAT/enhancer-binding protein (C/EBP) functions as a safeguard that enhances Treg cell generation by dampening the inhibitory effect of IFN-c and IL-4 on Foxp3 expression. These results establish C/EBP as a new molecular target for enhancing the formation and stability of Treg cells in inflammatory environments. |
About TF
| TF name : | -- |
| TF experiment: | Retroviral transduction,Intracellular staining,Quantitative real-time PCR,Chromatin immunoprecipitation assays,Bisulfite sequencing,Electrophoretic mobility shift assay |
| TF experiment description: | CCAAT/enhancer-binding protein (C/EBP) functions as a safeguard that enhances Treg cell generation by dampening the inhibitory effect of IFN-c and IL-4 on Foxp3 expression. These results establish C/EBP as a new molecular target for enhancing the formation and stability of Treg cells in inflammatory environments. |
About Function
| Enhancer function : | CCAAT/enhancer-binding protein (C/EBP) functions as a safeguard that enhances Treg cell generation by dampening the inhibitory effect of IFN-c and IL-4 on Foxp3 expression. These results establish C/EBP as a new molecular target for enhancing the formation and stability of Treg cells in inflammatory environments. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
CCAAT/enhancer-binding protein (C/EBP) functions as a safeguard that enhances Treg cell generation by dampening the inhibitory effect of IFN-c and IL-4 on Foxp3 expression. These results establish C/EBP as a new molecular target for enhancing the formation and stability of Treg cells in inflammatory environments. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene