About Enhancer
| Enhancer ID: |
E_02_0437 |
| Species: |
human |
| Position :
|
chr9:117701087-117703087
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
Acute lung injury (ali) |
| Pubmed ID: |
30187766
|
| Enhancer experiment: |
RT-PCR, Weston blot, immunofluorescence light staining, gene knockdown |
| Enhancer experiment description: |
Results: We identified significantly decreased STC1 expression in TLR4 knockout mouse lungs and primary lung endothelium isolated from TLR4 knockout mice. Overexpression of STC1 was associated with endothelial cytoprotection while decreased or insufficient expression was associated with increased oxidant-induced injury and death. |
About Target gene
| Target gene : |
TLR4(Lps,Ly87,Ran/M1,Rasl2-8),STC1 |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
Results: We identified significantly decreased STC1 expression in TLR4 knockout mouse lungs and primary lung endothelium isolated from TLR4 knockout mice. Overexpression of STC1 was associated with endothelial cytoprotection while decreased or insufficient expression was associated with increased oxidant-induced injury and death.; Results: We identified significantly decreased STC1 expression in TLR4 knockout mouse lungs and primary lung endothelium isolated from TLR4 knockout mice. Overexpression of STC1 was associated with endothelial cytoprotection while decreased or insufficient expression was associated with increased oxidant-induced injury and death. |
About TF
| TF name : |
-- |
| TF experiment: |
RT-PCR,weston blot,???????,???? |
| TF experiment description: |
Results: We identified significantly decreased STC1 expression in TLR4 knockout mouse lungs and primary lung endothelium isolated from TLR4 knockout mice. Overexpression of STC1 was associated with endothelial cytoprotection while decreased or insufficient expression was associated with increased oxidant-induced injury and death.; Results: We identified significantly decreased STC1 expression in TLR4 knockout mouse lungs and primary lung endothelium isolated from TLR4 knockout mice. Overexpression of STC1 was associated with endothelial cytoprotection while decreased or insufficient expression was associated with increased oxidant-induced injury and death. |
About Function
| Enhancer function : |
Results: We identified significantly decreased STC1 expression in TLR4 knockout mouse lungs and primary lung endothelium isolated from TLR4 knockout mice. Overexpression of STC1 was associated with endothelial cytoprotection while decreased or insufficient expression was associated with increased oxidant-induced injury and death. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
Results: We identified significantly decreased STC1 expression in TLR4 knockout mouse lungs and primary lung endothelium isolated from TLR4 knockout mice. Overexpression of STC1 was associated with endothelial cytoprotection while decreased or insufficient expression was associated with increased oxidant-induced injury and death. |
About SNP
Upstream Pathway Annotation of TF
| GeneName |
Pathway Name |
Source |
Gene Number |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs