About Enhancer
| Enhancer ID: | E_02_0445 |
| Species: | human |
| Position : | chr4:70515658-70517658   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Tumour |
| Pubmed ID: | 30158339 |
| Enhancer experiment: | Real time polymerase chain reaction (PCR), Weston blot, luciferase assays, gel shift assays, chromatin immunoprecipitation (chip) assays, statistical analysis |
| Enhancer experiment description: | AMTN-deficient mice have a hypo- mineralized inner enamel and structural defects in the outer enamel due to delayed expression of kallikrein-4 (8). During JE regeneration after gingivectomy, ODAM is first expressed at the leading edge of the wound and AMTN expression appears later, suggesting ODAM and AMTN have coordinated tasks at the cell-tooth interface (9). AMTN can promote hydroxyapatite mineralizati. |
About Target gene
| Target gene : | AMTN |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | AMTN-deficient mice have a hypo- mineralized inner enamel and structural defects in the outer enamel due to delayed expression of kallikrein-4 (8). During JE regeneration after gingivectomy, ODAM is first expressed at the leading edge of the wound and AMTN expression appears later, suggesting ODAM and AMTN have coordinated tasks at the cell-tooth interface (9). AMTN can promote hydroxyapatite mineralizati. |
About TF
| TF name : | -- |
| TF experiment: | Real-time polymerase chain reaction (PCR),weston blot,Luciferase assays,Gel shift assays,Chromatin immunoprecipitation (ChIP) assays,???? |
| TF experiment description: | AMTN-deficient mice have a hypo- mineralized inner enamel and structural defects in the outer enamel due to delayed expression of kallikrein-4 (8). During JE regeneration after gingivectomy, ODAM is first expressed at the leading edge of the wound and AMTN expression appears later, suggesting ODAM and AMTN have coordinated tasks at the cell-tooth interface (9). AMTN can promote hydroxyapatite mineralizati. |
About Function
| Enhancer function : | AMTN-deficient mice have a hypo- mineralized inner enamel and structural defects in the outer enamel due to delayed expression of kallikrein-4 (8). During JE regeneration after gingivectomy, ODAM is first expressed at the leading edge of the wound and AMTN expression appears later, suggesting ODAM and AMTN have coordinated tasks at the cell-tooth interface (9). AMTN can promote hydroxyapatite mineralizati. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
AMTN-deficient mice have a hypo- mineralized inner enamel and structural defects in the outer enamel due to delayed expression of kallikrein-4 (8). During JE regeneration after gingivectomy, ODAM is first expressed at the leading edge of the wound and AMTN expression appears later, suggesting ODAM and AMTN have coordinated tasks at the cell-tooth interface (9). AMTN can promote hydroxyapatite mineralizati. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene