About Enhancer
| Enhancer ID: | E_02_0482 |
| Species: | human |
| Position : | chr10:101128610-101130610   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | T-cell acute lymphoblastic leukemia |
| Pubmed ID: | 30107177 |
| Enhancer experiment: | QRT PCR, RNA SEQ, chip SEQ, fast ATAC SEQ, Weston blot, flow cytometry, statistical analysis |
| Enhancer experiment description: | Our data show that TLX1 and STAT5 directly cooperate at the transcriptional level through activation of enhancer regions of key proto-oncogenes such as MYC and BCL2. |
About Target gene
| Target gene : | TLX1,MYC(MRTLC,bHLHe39,c-Myc),BCL2(Bcl-2,PPP1R50) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Our data show that TLX1 and STAT5 directly cooperate at the transcriptional level through activation of enhancer regions of key proto-oncogenes such as MYC and BCL2. ;Our data show that TLX1 and STAT5 directly cooperate at the transcriptional level through activation of enhancer regions of key proto-oncogenes such as MYC and BCL2. ;Our data show that TLX1 and STAT5 directly cooperate at the transcriptional level through activation of enhancer regions of key proto-oncogenes such as MYC and BCL2. |
About TF
| TF name : | -- |
| TF experiment: | qRT-PCR,RNA-seq,ChIP-seq,Fast-ATAC-seq,weston blot,?????,???? |
| TF experiment description: | Our data show that TLX1 and STAT5 directly cooperate at the transcriptional level through activation of enhancer regions of key proto-oncogenes such as MYC and BCL2. ;Our data show that TLX1 and STAT5 directly cooperate at the transcriptional level through activation of enhancer regions of key proto-oncogenes such as MYC and BCL2. ;Our data show that TLX1 and STAT5 directly cooperate at the transcriptional level through activation of enhancer regions of key proto-oncogenes such as MYC and BCL2. |
About Function
| Enhancer function : | Our data show that TLX1 and STAT5 directly cooperate at the transcriptional level through activation of enhancer regions of key proto-oncogenes such as MYC and BCL2. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Our data show that TLX1 and STAT5 directly cooperate at the transcriptional level through activation of enhancer regions of key proto-oncogenes such as MYC and BCL2. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene