About Enhancer
| Enhancer ID: | E_02_0483 |
| Species: | human |
| Position : | chr5:88714837-88716837   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Pulmonary arterial hypertension |
| Pubmed ID: | 30106596 |
| Enhancer experiment: | Flow cytometry, immunofluorescence light staining |
| Enhancer experiment description: | MEF2 (myocyte enhancer factor 2) is a transcription factor that regulates multiple genes that are important during cardiovascular development and for vascular homeostasis (1), with MEF2C known to play a crucial role in regulating endothelial integrity, survival, and angiogenesis (2). Some of the results of these studies have been previously reported in the form of an abstract (5). Methods To investigate the role of endothelial MEF2 function in the pathogenesis of PH, we generated adult mice with inducible, endothelial-specific deletion of the Mef2c allele, using a tamoxifen-responsive Cdh5 promoter driven Cre recombinase crossed to mice with Mef2cfl/fl alleles (henceforth called Mef2cECKO mice) (6, 7). |
About Target gene
| Target gene : | MEF2C(5430401D19Rik,9930028G15Rik,AV011172,Mef2) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | MEF2 (myocyte enhancer factor 2) is a transcription factor that regulates multiple genes that are important during cardiovascular development and for vascular homeostasis (1), with MEF2C known to play a crucial role in regulating endothelial integrity, survival, and angiogenesis (2). Some of the results of these studies have been previously reported in the form of an abstract (5). Methods To investigate the role of endothelial MEF2 function in the pathogenesis of PH, we generated adult mice with inducible, endothelial-specific deletion of the Mef2c allele, using a tamoxifen-responsive Cdh5 promoter driven Cre recombinase crossed to mice with Mef2cfl/fl alleles (henceforth called Mef2cECKO mice) (6, 7). |
About TF
| TF name : | -- |
| TF experiment: | ?????,??????? |
| TF experiment description: | MEF2 (myocyte enhancer factor 2) is a transcription factor that regulates multiple genes that are important during cardiovascular development and for vascular homeostasis (1), with MEF2C known to play a crucial role in regulating endothelial integrity, survival, and angiogenesis (2). Some of the results of these studies have been previously reported in the form of an abstract (5). Methods To investigate the role of endothelial MEF2 function in the pathogenesis of PH, we generated adult mice with inducible, endothelial-specific deletion of the Mef2c allele, using a tamoxifen-responsive Cdh5 promoter driven Cre recombinase crossed to mice with Mef2cfl/fl alleles (henceforth called Mef2cECKO mice) (6, 7). |
About Function
| Enhancer function : | MEF2 (myocyte enhancer factor 2) is a transcription factor that regulates multiple genes that are important during cardiovascular development and for vascular homeostasis (1), with MEF2C known to play a crucial role in regulating endothelial integrity, survival, and angiogenesis (2). Some of the results of these studies have been previously reported in the form of an abstract (5). Methods To investigate the role of endothelial MEF2 function in the pathogenesis of PH, we generated adult mice with inducible, endothelial-specific deletion of the Mef2c allele, using a tamoxifen-responsive Cdh5 promoter driven Cre recombinase crossed to mice with Mef2cfl/fl alleles (henceforth called Mef2cECKO mice) (6, 7). |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
MEF2 (myocyte enhancer factor 2) is a transcription factor that regulates multiple genes that are important during cardiovascular development and for vascular homeostasis (1), with MEF2C known to play a crucial role in regulating endothelial integrity, survival, and angiogenesis (2). Some of the results of these studies have been previously reported in the form of an abstract (5). Methods To investigate the role of endothelial MEF2 function in the pathogenesis of PH, we generated adult mice with inducible, endothelial-specific deletion of the Mef2c allele, using a tamoxifen-responsive Cdh5 promoter driven Cre recombinase crossed to mice with Mef2cfl/fl alleles (henceforth called Mef2cECKO mice) (6, 7). |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene