About Enhancer
| Enhancer ID: | E_02_0502 |
| Species: | mouse |
| Position : | chr7:34815866-34817866   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 30061199 |
| Enhancer experiment: | Flow cytometry, statistical analysis, PCR |
| Enhancer experiment description: | Extending these findings, pan-hematopoietic murine Cebpa enhancer deletion using Mx1-Cre leads to expanded CLP, fewer preproB cells, markedly reduced proB and preB cells, and reduced mature B cells, without affecting T cell numbers. In contrast, enhancer deletion at the proB stage using Mb1-Cre does not impair B cell maturation. Introduction The C/EBP? basic region-leucine zipper transcription factor (TF) regulates myeloid development and transformation (1). Cebpa / mice manifest neonatal lethality due to hypoglycemia, with marked neutropenia but no reduction in splenic B220+ B cells or thymic CD4+ or CD8+ T cells (2). |
About Target gene
| Target gene : | Cebpa(C/ebpalpha,CBF-A,Cebp),TF |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Extending these findings, pan-hematopoietic murine Cebpa enhancer deletion using Mx1-Cre leads to expanded CLP, fewer preproB cells, markedly reduced proB and preB cells, and reduced mature B cells, without affecting T cell numbers. In contrast, enhancer deletion at the proB stage using Mb1-Cre does not impair B cell maturation. Introduction The C/EBP? basic region-leucine zipper transcription factor (TF) regulates myeloid development and transformation (1). Cebpa / mice manifest neonatal lethality due to hypoglycemia, with marked neutropenia but no reduction in splenic B220+ B cells or thymic CD4+ or CD8+ T cells (2).;Extending these findings, pan-hematopoietic murine Cebpa enhancer deletion using Mx1-Cre leads to expanded CLP, fewer preproB cells, markedly reduced proB and preB cells, and reduced mature B cells, without affecting T cell numbers. In contrast, enhancer deletion at the proB stage using Mb1-Cre does not impair B cell maturation. Introduction The C/EBP? basic region-leucine zipper transcription factor (TF) regulates myeloid development and transformation (1). Cebpa / mice manifest neonatal lethality due to hypoglycemia, with marked neutropenia but no reduction in splenic B220+ B cells or thymic CD4+ or CD8+ T cells (2). |
About TF
| TF name : | -- |
| TF experiment: | ?????,????,PCR |
| TF experiment description: | Extending these findings, pan-hematopoietic murine Cebpa enhancer deletion using Mx1-Cre leads to expanded CLP, fewer preproB cells, markedly reduced proB and preB cells, and reduced mature B cells, without affecting T cell numbers. In contrast, enhancer deletion at the proB stage using Mb1-Cre does not impair B cell maturation. Introduction The C/EBP? basic region-leucine zipper transcription factor (TF) regulates myeloid development and transformation (1). Cebpa / mice manifest neonatal lethality due to hypoglycemia, with marked neutropenia but no reduction in splenic B220+ B cells or thymic CD4+ or CD8+ T cells (2).;Extending these findings, pan-hematopoietic murine Cebpa enhancer deletion using Mx1-Cre leads to expanded CLP, fewer preproB cells, markedly reduced proB and preB cells, and reduced mature B cells, without affecting T cell numbers. In contrast, enhancer deletion at the proB stage using Mb1-Cre does not impair B cell maturation. Introduction The C/EBP? basic region-leucine zipper transcription factor (TF) regulates myeloid development and transformation (1). Cebpa / mice manifest neonatal lethality due to hypoglycemia, with marked neutropenia but no reduction in splenic B220+ B cells or thymic CD4+ or CD8+ T cells (2). |
About Function
| Enhancer function : | Extending these findings, pan-hematopoietic murine Cebpa enhancer deletion using Mx1-Cre leads to expanded CLP, fewer preproB cells, markedly reduced proB and preB cells, and reduced mature B cells, without affecting T cell numbers. In contrast, enhancer deletion at the proB stage using Mb1-Cre does not impair B cell maturation. Introduction The C/EBP? basic region-leucine zipper transcription factor (TF) regulates myeloid development and transformation (1). Cebpa / mice manifest neonatal lethality due to hypoglycemia, with marked neutropenia but no reduction in splenic B220+ B cells or thymic CD4+ or CD8+ T cells (2). |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Extending these findings, pan-hematopoietic murine Cebpa enhancer deletion using Mx1-Cre leads to expanded CLP, fewer preproB cells, markedly reduced proB and preB cells, and reduced mature B cells, without affecting T cell numbers. In contrast, enhancer deletion at the proB stage using Mb1-Cre does not impair B cell maturation. Introduction The C/EBP? basic region-leucine zipper transcription factor (TF) regulates myeloid development and transformation (1). Cebpa / mice manifest neonatal lethality due to hypoglycemia, with marked neutropenia but no reduction in splenic B220+ B cells or thymic CD4+ or CD8+ T cells (2). |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene